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The polyamino-isoprenyl enhancer NV716 enables the antibacterial activity of two families of multi-target inhibitors against the ESKAPEE bacterium Enterobacter cloacae

Emma Forest Jean Michel Brunel Jean-Michel Bolla Jean-François Cavalier Jordan Lehoux Alexandre Guy Thierry Durand Stéphane Audebert Luc Camoin Christopher D.Spilling Céline Crauste Stéphane Canaan

微生物（英文）2025，Vol.4Issue(3)：259-274,16.

微生物（英文）2025，Vol.4Issue(3)：259-274,16.DOI:10.1002/mlf2.70014

The polyamino-isoprenyl enhancer NV716 enables the antibacterial activity of two families of multi-target inhibitors against the ESKAPEE bacterium Enterobacter cloacae

Emma Forest ¹Jean Michel Brunel ²Jean-Michel Bolla ²Jean-François Cavalier ³Jordan Lehoux ⁴Alexandre Guy ⁴Thierry Durand ⁴Stéphane Audebert ⁵Luc Camoin ⁵Christopher D.Spilling ⁶Céline Crauste ⁴Stéphane Canaan³

作者信息

1. Aix Marseille Univ.,CNRS,LISM UMR7255,IMM FR3479,Marseille,France||Aix Marseille Univ,INSERM,SSA,MCT,Marseille,France
2. Aix Marseille Univ,INSERM,SSA,MCT,Marseille,France
3. Aix Marseille Univ.,CNRS,LISM UMR7255,IMM FR3479,Marseille,France
4. IBMM,Univ Montpellier,CNRS,ENSCM,Montpellier,France
5. Aix Marseille Univ,CNRS,INSERM,Institut Paoli-Calmettes,CRCM,Marseille Protéomique,Marseille,France
6. Department of Chemistry and Biochemistry,University of Missouri-St.Louis,St.Louis,Missouri,USA
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摘要

关键词

activity based-protein profiling/antibiotic resistance/Cyclipostins and Cyclophostin analogs/drug enhancers/oxadiazolone derivatives

Key words

activity based-protein profiling/antibiotic resistance/Cyclipostins and Cyclophostin analogs/drug enhancers/oxadiazolone derivatives

引用本文复制引用

Emma Forest,Jean Michel Brunel,Jean-Michel Bolla,Jean-François Cavalier,Jordan Lehoux,Alexandre Guy,Thierry Durand,Stéphane Audebert,Luc Camoin,Christopher D.Spilling,Céline Crauste,Stéphane Canaan..The polyamino-isoprenyl enhancer NV716 enables the antibacterial activity of two families of multi-target inhibitors against the ESKAPEE bacterium Enterobacter cloacae[J].微生物（英文）,2025,4(3):259-274,16.

基金项目

This study was supported by the CNRS,INSERM,and Aix Marseille University.Proteomics analyses were carried out using the mass spectrometry facility of Marseille Proteo-mics(marseille-proteomique.univ-amu.fr)supported by IBISA,the Cancéropôle PACA,the Provence-Alpes-Côte d'Azur Region,the Institut Paoli-Calmettes,and Fonds Européen de Développement Regional(FEDER).Emma Forest PhD fellowship is supported by the Ministère de l'Enseignement Supérieur et de la Recherche.The authors would like to thank Pierre Santucci(LISM UMR7255 CNRS)for his help with Biorender. （marseille-proteomique.univ-amu.fr）

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