西安交通大学学报（医学版）2025，Vol.46Issue(6)：925-929,5.DOI:10.7652/jdyxb202506005
超24小时大脑中动脉粥样硬化闭塞性急性缺血性卒中的血管内治疗
Endovascular therapy beyond 24 hours for middle cerebral artery atherosclerotic occlusion in acute ischemic stroke
摘要
Abstract
Objective To assess the clinical and safety outcomes of endovascular therapy(EVT)administered beyond 24 h after the onset of symptoms in patients with acute ischemic stroke(AIS)resulting from middle cerebral artery atherosclerotic occlusion.Methods We enrolled consecutive AIS patients with middle cerebral artery atherosclerotic occlusion who received EVT in our hospital between January 2020 and June 2023 and divided them into two groups based on the time from AIS onset to EVT:EVT≤24 h group and EVT＞24 h group.The National Institutes of Health Stroke Scale(NIHSS)scores after surgery,90-day functional independence(defined as mRS 0-2),symptomatic ICH(sICH),postoperative acute thrombosis,as well as mortality,were analyzed in the two groups of patients.Results A total of 161 patients were recruited,with 106 cases in the EVT≤24 h group and 55 cases in the EVT＞24 h group.The NIHSS scores declined after EVT in both groups(P＜0.01).The NIHSS scores after surgery were lower in the EVT≤24 h group(median:4.5 vs.7.0,P＜0.05).90-day functional independence(45.3％vs.30.9％,95％CI:0.93-3.68),sICH(5.7％vs.9.1％,95％CI:0.18-2.06),postoperative acute thrombosis(6.6％vs.3.6％,95％CI:0.37-9.34),and mortality(3.8％vs.1.8％,95％CI:0.23-19.42)did not differ significantly between the groups(P＞0.05).Conclusion Our findings support EVT feasibility in selected patients with middle cerebral artery atherosclerotic occlusion beyond 24 h.Prospective studies are warranted for confirmation.关键词
急性缺血性脑卒中(AIS)/血管内治疗(EVT)/超晚时间窗/大脑中动脉/动脉粥样硬化Key words
acute ischemic stroke(AIS)/endovascular therapy(EVT)/very late time window/middle cerebral artery/atherosclerosis分类
医药卫生引用本文复制引用
关敏,乔宏宇,杨冰,辛秀峰,黄声明,张亮,林英泽,梁洁..超24小时大脑中动脉粥样硬化闭塞性急性缺血性卒中的血管内治疗[J].西安交通大学学报（医学版）,2025,46(6):925-929,5.基金项目
广东省医学科学技术研究基金(No.B2022239)Supported by the Medical Science and Technology Research Foundation of Guangdong Province(No.B2022239) （No.B2022239）
