西安交通大学学报（医学版）2025，Vol.46Issue(6)：953-959,7.DOI:10.7652/jdyxb202506009
聚羟基乙酸/羟丙基甲基纤维素复合材料用于犬胃管状切除术后缝合的效果研究
Effectiveness of polyglycolicacid/hydroxypropyl methylcellulose composite materials for suturing after canine gastric tubular resection
摘要
Abstract
Objective To explore the effectiveness and safety of polyglycolic acid(PGA)and hydroxypropyl methylcellulose(HPMC)composite materials for suturing after canine sleeve gastrectomy.Methods A total of 36 healthy Beagle dogs were randomly divided into experimental group and control group in a 1∶1 male-to-female ratio.The experimental group underwent gastric sleeve resection with PGA+HPMC composite material for suture reinforcement,while the control group used NV-ET-M60E-2 suture material.Postoperative monitoring included survival status,food intake,and body temperature changes.Venous blood samples were collected before surgery,3 days after surgery,and before euthanasia for routine blood tests.At 2,4,and 8 weeks postoperatively,six dogs were euthanized at each time point for histological examination,hard tissue pathological evaluation,and safety assessment of the heart,liver,spleen,lungs,and kidneys.Results There were no significant differences in blood routine test results between the control group and the experimental group(P＞0.05).Before dissection,the percentage of basophils was significantly higher in the control group than in the experimental group(P=0.015).At 2 weeks after surgery,the severity of liver cell edema in the control group was higher than in the experimental group(P=0.036).However,the two groups did not significantly differ in the histological examination results of the heart,liver,spleen,lungs,or kidneys at other time points(P＞0.05).Hard tissue pathological slice results at 2,4,and 8 weeks after surgery showed no material residue in either group by the 8th week,and there were no significant differences in inflammation and necrosis scores or fibrosis/fat infiltration totals between the two groups(P＞0.05).Inflammation scores and fibrosis/fat infiltration totals at 8 weeks post-operation were significantly lower than those at 2 weeks post-operation(P＜0.05).During the experiment,no near-death phenomena occurred in either group,and no fever or refusal to eat was observed within 3 days after surgery.At dissection,the Beagle dogs appeared normal with glossy fur and no abnormal secretions.Conclusion PGA+HPMC composite materials can be effectively degraded and used as non-toxic suture fixation materials for wound suturing after sleeve gastrectomy,providing a theoretical basis for their clinical application.关键词
聚羟基乙酸(PGA)/羟丙基甲基纤维素(HPMC)/生物降解材料/术后缝合固定/组织修复/术后恢复Key words
polyglycolic acid(PGA)/hydroxypropyl methylcellulose(HPMC)/biodegradable material/postoperative suture fixation/tissue repair/postoperative recovery分类
临床医学引用本文复制引用
张风华,吴雪烁,王宝枝,夏宇晓,松谷哲行,冯巨滨..聚羟基乙酸/羟丙基甲基纤维素复合材料用于犬胃管状切除术后缝合的效果研究[J].西安交通大学学报（医学版）,2025,46(6):953-959,7.基金项目
广东省医学科研基金资助(No.A2023475)Supported by the Guangdong Medical Science Research Fund(No.A2023475) （No.A2023475）
