西安交通大学学报（医学版）2025，Vol.46Issue(6)：966-973,8.DOI:10.7652/jdyxb202506011
血浆致动脉粥样硬化指数与代谢功能障碍相关脂肪性肝病的相关性
Correlation between atherogenic index of plasma and metabolism-associated steatotic liver disease
摘要
Abstract
Objective To investigate the association between plasma atherogenic index of plasma(AIP)and metabolism-associated steatotic liver disease(MASLD),and to evaluate the potential value of AIP as a predictive marker for MASLD risk.Methods We enrolled a total of 4 850 health check-up participants from The Second Affiliated Hospital of Xi'an Jiaotong University between June 2021 and May 2023.The participants were divided into quartiles(Q1-Q4)according to their AIP level.Biochemical indicators and MASLD prevalence were compared across groups.Logistic regression,subgroup analysis,and restricted cubic splines(RCS)were used to explore the relationship between AIP and MASLD.Results Among the 4 850 participants,the prevalence of MASLD was 26.08％(1 265/4 850).MASLD prevalence increased across AIP quartiles:4.0％,13.8％,30.8％,and 55.6％in Q1-Q4,respectively(P＜0.001).Compared with Q1,Q2-Q4 groups showed higher proportions of males,BMI,smokers,overweight/obesity,central obesity,prediabetes,hypertension,serum uric acid,and fatty liver index(FLI)(all P＜0.001).Lipid profiles worsened with increased AIP:total cholesterol,triglycerides,and LDL-C increased,while HDL-C decreased(P＜0.001).RCS analysis demonstrated a significant linear relationship between AIP and MASLD risk.After adjusting for confounders,the participants in Q4 had an 8.71-fold higher risk of MASLD than those in Q1(OR:8.71,95％CI:6.20-12.23,P＜0.001).A composite model incorporating AIP,BMI,and FLI showed superior discriminative performance(AUC:0.883,95％CI:0.873-0.892).Interaction analysis suggested that AIP had significant interactions with BMI,hypertension,and prediabetes(P＜0.05).In individuals without these metabolic abnormalities,the association between AIP and MASLD was more pronounced.Conclusion Elevated AIP was significantly associated with an increased risk of MASLD,with a stronger association observed in individuals with normal BMI,blood pressure,and blood glucose levels,suggesting that AIP may serve as a potential indicator for early screening of MASLD.关键词
代谢功能障碍相关脂肪性肝病(MASLD)/血浆致动脉粥样硬化指数(AIP)/三酰甘油/高密度脂蛋白胆固醇Key words
metabolism-associated steatotic liver disease(MASLD)/atherogenic index of plasma(AIP)/triglyceride/high-density lipoprotein cholesterol分类
临床医学引用本文复制引用
李盈,张春艳,高希羽,闫保娥,白迪,刘根,肖静,王倩,张岩,韩拓..血浆致动脉粥样硬化指数与代谢功能障碍相关脂肪性肝病的相关性[J].西安交通大学学报（医学版）,2025,46(6):966-973,8.基金项目
陕西省自然科学基金项目(No.2024JC-YBQN-0819) （No.2024JC-YBQN-0819）
西安市科技计划项目(No.24YXYJ0148) （No.24YXYJ0148）
西安交通大学第二附属医院科研基金青年项目[No.YJ(QN)202325]Supported by the Natural Science Basic Research Program of Shaanxi Province(No.2024JC-YBQN-0819),Xi'an Science and Technol-ogy Plan Project(No.24YXYJ0148),and Scientific Research Fund Youth Project of The Second Affiliated Hospital of Xi'an Jiaotong University[No.YJ(QN)202325] （QN）
