西安交通大学学报（医学版）2025，Vol.46Issue(6)：1045-1052,8.DOI:10.7652/jdyxb202506023
1990-2021年全球与中国新生儿先天性出生缺陷疾病负担趋势分析
Trends in the disease burden of neonatal congenital birth defects in China and the globe,1990-2021
摘要
Abstract
Objective To analyze the long-term trend in the disease burden of congenital birth defects(CBDs)among neonates in China from 1990 to 2021,compare the trend with global patterns,and identify key subtypes along with their association with socioeconomic status to provide evidence for public health interventions.Methods Utilizing data from the Global Burden of Disease Study 2021(GBD 2021),we extracted indicators including disability-adjusted life years(DALYs),mortality,and prevalence for the neonatal period(＜28 days)in China,encompassing ten major CBD subtypes.Joinpoint regression analysis was employed to calculate annual percent changes and estimate annual percent changes(EAPC),with comparisons of subtype composition between 1990 and 2021.Nonlinear regression was used to assess the relationship between DALYs rates and the Socio-demographic Index(SDI).Results From 1990 to 2021,DALYs rates for neonatal CBDs declined significantly both globally and in China,with China's EAPC at-4.67％[95％CI:(—5.06,—4.28)],substantially exceeding the global average of-1.70％[95％CI:(—1.75,—1.64)].Congenital heart anomalies remained the primary burden,while neural tube defects and orofacial clefts in China showed notable reductions(EAPCs of-7.25％and-11.22％,respectively).However,DALYs rates for congenital musculoskeletal and limb anomalies exceeded global expected levels.A resurgence in the prevalence was observed post-2015,with higher burdens in males.DALYs rates exhibited a negative correlation with SDI.Conclusion China has achieved significant reductions in the neonatal CBDs burden,surpassing global trends;yet challenges persist in managing congenital heart anomalies and musculoskeletal defects.Future efforts should focus on enhancing early screening,surgical interventions,and regional equity to align with global health objectives.关键词
先天性出生缺陷/新生儿/疾病负担/趋势分析Key words
congenital birth defect/neonate/burden of disease/trend analysis分类
临床医学引用本文复制引用
吕华胜,冀伟,孙丰宇,沈好亮,拉再依·巴合提,袁腾,陈铀..1990-2021年全球与中国新生儿先天性出生缺陷疾病负担趋势分析[J].西安交通大学学报（医学版）,2025,46(6):1045-1052,8.基金项目
新疆维吾尔自治区自然科学基金资助项目(No.2022D01E71) （No.2022D01E71）
新疆维吾尔自治区天山英才-青年拔尖科技人才项目(No.2022TSYCCX0101)Supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region(No.2022D01E71)and the Top Young Scientific and Technological Talents of the Tianshan Talent Cultivation Program in Xinjiang(No.2022TSYCCX0101) （No.2022TSYCCX0101）
