现代妇产科进展2025，Vol.34Issue(11)：821-825,5.DOI:10.13283/j.cnki.xdfckjz.2025.11.036
昆明高海拔地区孕妇维生素D水平及VDR基因多态性对妊娠期糖尿病的影响
Impact of Vitamin D levels and VDR gene polymorphisms on gestational diabetes melli-tus in pregnant women from high-altitude areas of Kunming
摘要
Abstract
Objective:To explore the impact of serum 25-hydroxyvitamin D(25(OH)D)levels and Vitamin D receptor(VDR)gene polymorphisms(BsmI,FokI,ApaI,TaqI)on the occurrence of gestational diabetes mellitus(GDM)in pregnant women from high-altitude regions ofKunming,and to assess their potential as predictive factors.Methods:A prospective study was conducted on 57 pregnant women undergoing prenatal examinations between June 2019 and June 2020,divided into GDM group(25 cases),insulin-requiring GDM(GDM-RI)group(6 ca-ses),and normal pregnancy group(26 cases).Serum 25(OH)D levels,homeostasis model as-sessment of insulin resistance(HOMA-IR),and VDR gene polymorphisms were measured and analyzed for their associations with GDM.Results:The 25(OH)D levels in the GDM and GDM-RI groups were significantly lower than those in the normal group(P<0.05),and negatively correlated with HOMA-IR(r=-0.393,P=0.002).The B allele frequency of the VDR BsmI polymorphism was higher in the GDM-RI group(P<0.05).Multivariate logistic regression anal-ysis indicated that only 25(OH)D was an independent predictor of GDM(OR=0.184,95%CI:0.053～0.647).Conclusion:In high-altitude regions of Kunming,Vitamin D deficiency may increase GDM risk by exacerbating insulin resistance,while VDR BsmI polymorphism may be involved in disease progression.Further studies with larger sample sizes are needed to validate these findings.关键词
妊娠期糖尿病/维生素D/维生素D基因多态性/胰岛素抵抗Key words
Gestational diabetes/Vitamin D/Vitamin D gene polymorphism/Insulin resistance分类
临床医学引用本文复制引用
宋欣燕,陈楠楠,骆晶..昆明高海拔地区孕妇维生素D水平及VDR基因多态性对妊娠期糖尿病的影响[J].现代妇产科进展,2025,34(11):821-825,5.基金项目
云南省基础研究计划昆医联合专项青年博士项目[No:2018FE001(-311)] （-311）
