现代医药卫生2025，Vol.41Issue(11)：2497-2505,9.DOI:10.3969/j.issn.1009-5519.2025.11.001
肿瘤免疫治疗:从机制探索到临床精准化治疗
Tumor immunotherapy:from mechanism exploration to clinical precision treatment
摘要
Abstract
In recent years,tumor immunotherapy has achieved breakthrough progress in clinical appli-cations,significantly extending survival periods for some advanced cancer patients while improving their quali-ty of life.Currently,immunotherapy strategies mainly include immune checkpoint inhibitors,adoptive cell therapy,oncolytic viruses,tumor vaccines,and cytokines,etc.These therapies enhance the immunogenicity of tumor cells,activate effector immune cells,remodel the tumor microenvironment,and improve the overall function of the body's immune system through multiple mechanisms.However,the immune escape of tumor cells caused by immune tolerance and exhaustion,the high heterogeneity of tumor cells,and individual differ-ences greatly limit the efficacy of immunotherapy.Combined immunotherapy and individualized treatment strategies have shown great potential.Through precise intervention,"cold"tumors lacking immune cell infil-tration can be transformed into"hot"tumors with active immunity,achieving multiple synergistic anti-tumor effects.In the future,we should focus on the research and development of precise combination therapy,treat-ment safety optimization,individualized diagnosis and treatment strategies,and efficient targeted delivery tech-nologies,in order to promote the advancement of tumor immunotherapy towards higher efficacy and better controllability.关键词
肿瘤免疫治疗/免疫检查点/CAR-T细胞治疗/溶瘤病毒/肿瘤疫苗Key words
Tumor immunotherapy/Immune checkpoints/CAR-T cell therapy/Oncolytic viruses/Tumor vaccines分类
医药卫生引用本文复制引用
周旭,董睿,陈家乐,郑晓青,周洁..肿瘤免疫治疗:从机制探索到临床精准化治疗[J].现代医药卫生,2025,41(11):2497-2505,9.基金项目
国家自然科学基金项目(81925018 （）
82130049 （）
82430055). （）
