现代医药卫生2025，Vol.41Issue(11)：2515-2518,2523,5.DOI:10.3969/j.issn.1009-5519.2025.11.003
7种肿瘤相关自身抗体在肺癌诊断中的性能评估
Performance evaluation of seven tumor-associated autoantibodies in the diagnosis of lung cancer
摘要
Abstract
Objective To evaluate the value and advantages of single and combined detection of seven tumor-associated autoantibodies(TAAbs)in the early diagnosis of lung cancer.Methods A total of serum samples were collected from our hospital from January 2022 to June 2023,including 83 cases of lung cancer,40 cases of benign lung lesions,11 cases of other tumors and 115 healthy controls.The levels of 7-TAAbs(p53,SOX2,PGP9.5,GAGE7,GBU4-5,CAGE,MAGE A1)in 249 serum samples were detected by enzyme-linked immunosorbent assay(ELISA).Results The receiver operating characteristic(ROC)curve was used to evalu-ate the diagnostic efficacy of 7-TAAbs for lung cancer.The results showed that the expression levels of GAGE7,GBU4-5,MAGE A1 and CAGE were significantly different among the four groups(P<0.05).There was no significant difference in the expression levels of p53,PGP9.5 and SOX2(P>0.05).The sensitivity of combined detection for lung cancer diagnosis reached 56.63%,which was significantly higher than that of any single antibody detection.The specificity analysis showed that GAGE7 was the highest(100.00%),and the specificity of combined detection was further improved to 91.57%.The AUC of 7-TAAbs combined detection was 0.733,which was significantly better than that of single antibody detection(P<0.05).The positive rate of combined detection of 7-TAAbs in the four groups was also higher than that of single antibody detection(P<0.05).Conclusion The combined detection of 7-TAAbs significantly improves the early diagnostic effi-cacy of lung cancer,and can effectively identify lung cancer from benign lung lesions and other tumors.关键词
肿瘤相关自身抗体/肺癌/诊断Key words
Tumor-associated autoantibodies/Lung cancer/Diagnosis分类
医药卫生引用本文复制引用
张晓梅,王佳美,杨美娟,叶华,杨森,马华瑜,张兴旺..7种肿瘤相关自身抗体在肺癌诊断中的性能评估[J].现代医药卫生,2025,41(11):2515-2518,2523,5.基金项目
甘肃省自然科学基金项目(17JR5RA040) （17JR5RA040）
甘肃省人民医院院内科研基金项目(20GSSY3-19). （20GSSY3-19）
