现代医药卫生2025，Vol.41Issue(11)：2519-2523,5.DOI:10.3969/j.issn.1009-5519.2025.11.004
肺腺癌中COL1A1表达及其功能的生物信息学分析
Bioinformatics analysis of COL1A1 expression and function in lung adenocarcinoma
摘要
Abstract
Objective To analyze the expression of COL1A1 in lung adenocarcinoma tissues and its re-lationship with prognosis and biological function through bioinformatics techniques.Methods The expression differences of COL1A1 in lung adenocarcinoma and normal lung tissues were analyzed using the GEPIA data-base and verified through the HPA database.The ROC curve was constructed to analyze the predictive value of COL1A1 in the prognosis of lung adenocarcinoma.Draw the Kaplan-Meier curve for survival analysis.Then,through the String database,the top 10 proteins most closely related to the COL1A1 protein(COL1A2,COL3A1,COL5A2,SPARC,LUM,PCOLCE,ADAMTS2,BMP1,ITGB1,RUNX2)were obtained.The bio-logical functions of the relevant proteins were analyzed through R software.Results Compared with normal lung tissues,COL1A1 was significantly highly expressed in lung adenocarcinoma tissues(P<0.01).The ROC curve showed that COL1A1 had a good predictive value between lung adenocarcinoma and normal lung tissue.Compared with the low-expression group of COL1A1,the OS of the high-expression group of COL1A1 was poorer(P<0.05).The top 10 proteins closely related to COL1A mainly play a role in collagen fiber tissue,fi-brillary collagen trimer,extracellular matrix structural components,protein digestion and absorption,etc.Con-clusion The abnormal expression of COL1A1 is involved in the occurrence and development of lung adeno-carcinoma,and may be a target for diagnosis and treatment of lung adenocarcinoma.However,the specific function of COL1A1 in lung adenocarcinoma needs to be further studied in vitro.关键词
肺腺癌/Ⅰ型胶原蛋白α1/生物信息学/预后/数据库Key words
Lung adenocarcinoma/COL1A1/Bioinformatics/Prognosis/Database分类
临床医学引用本文复制引用
邢龙,吴双丽,袁胜利,李保健,徐敬宣,王丽娟,喻光..肺腺癌中COL1A1表达及其功能的生物信息学分析[J].现代医药卫生,2025,41(11):2519-2523,5.基金项目
青岛滨海学院附属医院临床科学研究专项项目(2024KYZ03 （）
2024KYY06). （）
