现代医药卫生2025，Vol.41Issue(11)：2524-2531,8.DOI:10.3969/j.issn.1009-5519.2025.11.005
乙状结肠镜筛查降低结直肠癌发生率和病死率的meta分析
Meta-analysis of flexible sigmoidoscopy in reducing colorectal cancer incidence and mortality
摘要
Abstract
Objective To evaluate the effect of flexible sigmoidoscopy(FS)screening on the incidence and mortality of colorectal cancer(CRC).Methods The related research published in PubMed,Embase,Web of science,Cochrane Library,CNKI,Wanfang database,VIP database and other databases from its establish-ment to February 2024 was searched.The screening group conducted screening based on FS,while the control group did not take intervention measures.Meta-analysis was carried out with Review Manager5.4 software.The main outcome indicators include CRC incidence/mortality,proximal colon cancer incidence/mortality,dis-tal CRC incidence/mortality,male CRC incidence/mortality,female CRC incidence/mortality and so on.Re-sults A total of four randomized controlled trials(RCT)were included.FS screening could reduce the inci-dence and mortality of CRC by 20%and 24%,with statistical significance(risk ratio=0.80,0.76,95%CI 0.75-0.86,0.70-0.82,P<0.000 01).Compared with the control group,the incidence and mortality of CRC in the screening group decreased by 32%and 36%,with statistical significance(risk ratio=0.68,0.64,95%CI 0.60-0.77,0.49-0.83,P<0.000 01,0.000 70).There was no significant difference in incidence and mortal-ity of proximal colon cancer.When FS was employed for population screening,the benefits accrued to men were more substantial than those for women.Specifically,the incidence rates were decreased by 25%in men and 12%in women,while the mortality rates were lowered by 31%in men and 14%in women.All of these differences were statistically significant(P<0.05).Conclusion FS screening can reduce the incidence and mortality rate of CRC,and when used for screening the population,men benefit more than women.It should be noted that the effect of FS screening on proximal colon cancer is not obvious.关键词
结直肠肿瘤/乙状结肠镜/发生率/病死率/Meta分析Key words
Colorectal neoplasms/Flexible sigmoidoscopy/Incidence rate/Mortality rate/Meta-analysis分类
临床医学引用本文复制引用
雷双宏,王晓英..乙状结肠镜筛查降低结直肠癌发生率和病死率的meta分析[J].现代医药卫生,2025,41(11):2524-2531,8.基金项目
甘肃省肛肠疾病临床医学研究中心基金项目(20JR10RA434). （20JR10RA434）
