现代医药卫生2025，Vol.41Issue(11)：2532-2536,5.DOI:10.3969/j.issn.1009-5519.2025.11.006
ACTB基因在肝细胞癌中的研究进展
Research progress of ACTB gene and hepatocellular carcinoma
摘要
Abstract
This study aims to comprehensively investigate the multifaceted roles of β-actin(ACTB)in the occurrence and progression of hepatocellular carcinoma(HCC),thereby providing novel insights for clinical diagnosis and targeted therapy.Firstly,based on the epidemiological data of HCC at home and abroad,the practical predicament of high incidence,difficulty in early diagnosis and limited treatment options of this dis-ease was emphasized,and the potential of cytoskeletal proteins in tumor biology had not been fully explored.Subsequently,by integrating large-scale transcriptome and single-cell sequencing data,the system systemati-cally revealed the abnormally upregulated expression pattern of ACTB in HCC tissue and cell models,and fur-ther proved that it was closely related to the accelerated proliferation of tumor cells,enhanced migration and invasion,and increased resistance to conventional chemotherapy.At the molecular level,it was clarified that ACTB collaboratively regulates epithelial-mesenchymal transition,cytoskeletal dynamics,and immune escape in the tumor microenvironment by reconstructing the actin network and activating key signaling pathways such as Wnt/β-catenin and PI3K/AKT.Finally,the article reviewed the development process of small mole-cule inhibitors,specific antibodies and RNA interference strategies targeting ACTB,analyzed the challenges of drug delivery and tumor-specific targeting,and proposed a new combined diagnosis and treatment model that integrates individualized gene expression profiles of patients and used high-throughput functional screening and precision medicine platforms.In order to significantly improve the prognosis and quality of life of HCC pa-tients.关键词
ACTB基因/肝细胞癌/肿瘤/治疗策略/综述Key words
ACTB gene/Hepatocellular carcinoma/Tumor/Treatment strategy/Review分类
临床医学引用本文复制引用
冯润林,梁雪婷,王一芃,汪毓寅,陆文杰,张佳欣,王虹粤,李永盛..ACTB基因在肝细胞癌中的研究进展[J].现代医药卫生,2025,41(11):2532-2536,5.基金项目
云南省高层次卫生健康技术人才培养经费资助项目(H-2024017) （H-2024017）
云南省基础研究计划项目(202501AT070489) （202501AT070489）
云南省基础研究计划昆医联合专项(202401AY070001-080) （202401AY070001-080）
昆明医科大学大学生创新训练计划项目(2024CYD065 （）
2024CYD434 （）
2024CYD439) （）
云南省昆明医科大学第二附属医院人才梯队培育项目(RCTDHB-202305). （RCTDHB-202305）
