现代医药卫生2025，Vol.41Issue(11)：2537-2544,2551,9.DOI:10.3969/j.issn.1009-5519.2025.11.007
循环核酸在胰腺癌液体活检中的应用研究进展
Research progress on the application of circulating nucleic acids in liquid biopsy for pancreatic cancer
章燕 1胡俊2
作者信息
- 1. 重庆理工大学药学与生物工程学院,重庆 400054
- 2. 重庆理工大学药学与生物工程学院,重庆 400054||陆军军医大学第一附属医院神经内科,重庆 400038
- 折叠
摘要
Abstract
Pancreatic cancer is a very aggressive malignant tumour.Its early symptoms are not obvious and it progresses rapidly,resulting in most patients being diagnosed at an advanced stage.The early diagnosis of existing screening methods is ineffective,and the development of non-invasive,cost-effective,and accurate novel biomarkers is a major challenge at present.Circulating nucleic acids,as non-invasive detection markers,have great potential for early diagnosis,prognostic assessment and treatment monitoring of pancreatic cancer.This review summarises the clinical value of circulating nucleic acids associated with pancreatic cancer in early diagnosis and prognostic assessment,focuses on the differences in clinical performance between free circulating nucleic acids(free-DNAs)and exosomal circulating nucleic acids(exo-DNAs),and highlights the prospects of multi-target combination testing.It aims to provide clinicians with a comprehensive overview of circulating nu-cleic acids as biomarkers,facilitating the early diagnosis,prognosis assessment,treatment and recurrence mo-nitoring of pancreatic cancer.关键词
胰腺癌/循环核酸/外泌体/早期诊断/预后评估/综述Key words
Pancreatic cancer/Circulating nucleic acids/Exosomes/Early diagnosis/Prognostic assessment/Review分类
医药卫生引用本文复制引用
章燕,胡俊..循环核酸在胰腺癌液体活检中的应用研究进展[J].现代医药卫生,2025,41(11):2537-2544,2551,9.
