现代医药卫生2025，Vol.41Issue(11)：2593-2596,2603,5.DOI:10.3969/j.issn.1009-5519.2025.11.017
AAR、FIB-4、APRI在AIH相关肝硬化诊断中的价值
The value of AAR,FIB-4,and APRI in the diagnosis of of AIH-related liver cirrhosis
摘要
Abstract
Objective To explore the clinical significance of three noninvasive indicators,namely the ra-tio of aspartate aminotransferase to alanine aminotransferase(AAR),factor 4 index of liver fibrosis(FIB-4),and the ratio of aspartate aminotransferase to platelets(APRI),in predicting liver cirrhosis related to autoim-mune hepatitis(AIH).Methods A total of 215 patients with AIH treated in Chongqing Public Health Medical Center from January 217 to September 2024 were selected as the study group,and according to whether the study group had cirrhosis,they were divided into AIH-related cirrhosis group(43 cases)and the non-liver cir-rhosis group(172 cases).Another 200 healthy people who underwent physical examinations during the same period were selected as the control group.The differences in AAR,FIB-4,and APRI among different groups were compared,the predictive value of these three indicators for AIH-related cirrhosis was analyzed.Results The AAR,FIB-4,and APRI in the study group were 1.30(0.97-1.63),2.42(1.69-5.10),and 0.82(0.45-1.45),respectively,significantly higher than those in the control group,1.13(0.95-1.33),1.13(0.91-1.37),0.26(0.20-0.32),and the differences were statistically significant(P<0.05).The AAR,FIB-4 and APRI in the AIH-related cirrhosis group were 1.63(1.48-2.03),6.38(5.19-8.00),and 2.01(1.14-3.33),respectively,which were all significantly higher than those in the non-cirrhosis group,1.25(0.94-1.50),1.56(1.95-3.52),0.71(0.41-1.23),and the differences were statistically significant(P<0.05).AAR,FIB-4 and APRI were included in the binary logistic regression analysis.Eventually,AAR and FIB-4 were screened out as independent predictors for diagnosing AIH-related liver cirrhosis(P<0.05).The area under the ROC curve of the combined prediction of AAR and FIB-4 for AIH-related liver cirrhosis was 0.947,which was significantly higher than that of other indicators(P<0.05),and the prediction sensitivity and speci-ficity were 0.945 and 0.907,respectively.Conclusion AAR and FIB-4 have high application value in predic-ting AIH-related liver cirrhosis.关键词
自身免疫性肝炎/肝硬化/天门冬氨酸氨基转移酶/血小板计数Key words
Autoimmune hepatitis/Liver cirrhosis/Aspartate aminotransferase/Platelet count分类
临床医学引用本文复制引用
张娅,温缘缘,姜海蓉..AAR、FIB-4、APRI在AIH相关肝硬化诊断中的价值[J].现代医药卫生,2025,41(11):2593-2596,2603,5.基金项目
重庆市科学技术局重点项目(cstc2020jscx-cylhX0001) （cstc2020jscx-cylhX0001）
重庆市公共卫生医疗救治中心项目(2019YNXM06). （2019YNXM06）
