摘要
Abstract
Objective To observe the effect of Jianwei Xiaopi Decoction on digestive function and nutri-tional status after radical gastrectomy for gastric cancer.Methods A total of 100 patients with gastric cancer admitted to Nanyang Zhang Zhongjing Hospital from June 2021 to August 2023 were selected as the research subjects and randomly divided into the conventional group and the traditional Chinese medicine group,with 50 cases in each group.Both groups of patients underwent laparoscopic radical gastrectomy for gastric cancer.The conventional group was given conventional nutritional support after the operation,while the traditional Chinese medicine group was treated with Jianpi Yangwei Decoction on the basis of the conventional group's treatment.After the treatment,both groups were followed up for one year to compare the digestive function,nutritional status,immune function,survival status and adverse reactions of the two groups.Results Under different treatment regimens,gastrin(GAS),motilin(MLT),pepsin Ⅰ(PG-Ⅰ)and pepsin Ⅱ(PG-Ⅱ)in Chi-nese medicine group were(25.23±5.28)ng/L,(205.45±20.36)ng/L,(142.11±20.45)ng/mL and(78.66±10.28)ng/mL,respectively.They were higher than those in the conventional group[(22.19±5.43)ng/L,(192.33±20.49)ng/L,(130.43±20.39)ng/mL,(73.36±10.41)ng/mL](t=2.838,3.212,2.860,2.562,P<0.05).Albumin(PA),hemoglobin(Hb),serum albumin(ALB)and serum transferrin(TRF)in the Chi-nese medicine group were(220.39±20.38)mg/L,(105.39±20.22)g/L,(34.29±5.16)g/L and(3.03±0.49)g/L,respectively.All of them were higher than those in conventional group[(207.22±20.37)mg/L,(92.33±10.36)g/L,(31.15±5.22)g/L,(2.42±0.45)g/L](t=3.232,4.065,3.025,6.484;P<0.05).The T lymphocyte subsets CD3+,CD4+,CD4+/CD8+in TCM group were higher than those in conventional group,and CD8+was lower than those in conventional group(t=2.611,3.249,6.885,2.466;P<0.05).By the end of follow-up,the functional status score(KPS)of the Chinese medicine group(88.49±10.23)scores was higher than that of the conventional group(83.22±10.45)scores.The score of ECOG-PS(1.15±0.34)scores in the Eastern Oncology group was lower than that in the conventional group(2.06±0.21)scores(t=2.548,16.102;P<0.05).There was no significant difference in the incidence of adverse reactions between the TCM group and the conventional group(P>0.05).Conclusion Jianwei Xiaopi Decoction can promote the re-covery of digestive function in patients after radical gastrectomy for gastric cancer.It can effectively improve the nutritional status and immune function of the body without increasing treatment risks,and improve the survival rate and quality of life of patients.关键词
胃癌根治术/健脾养胃汤/消化功能/营养状态/生存情况Key words
Radical gastrectomy for gastric cancer/Jianpi Yangwei Decoction/Digestive function/Nu-tritional status/Survival situation分类
医药卫生
