心脑血管病防治2025，Vol.25Issue(10)：11-14,23,5.DOI:10.3969/j.issn.1009-816x.2025.10.003
急性缺血性脑卒中患者外周血新型炎症标志物水平与颈动脉斑块易损性的相关性研究
Correlation between peripheral blood novel inflammatory markers and carotid plaque vulnerability in patients with acute ischemic stroke
摘要
Abstract
Objective To investigate the correlation between novel inflammatory biomarkers in peripheral blood and carotid plaque vulnerability in patients with acute ischemic stroke(AIS),and assess their predictive value for carotid plaque vulnerability.Methods A total of 146 AIS patients with carotid plaque thickness≥2.5 mm,identified by carotid ultrasonography at the North China University of Science and Technology Affiliated Hospital from March 2022 to October 2023 were selected.Based on superb microvascular imaging(SMI)examination of carotid plaque neovascularization,the patients were divided into a high-grade subgroup(104 cases)and a low-grade subgroup(42 cases).Patients'peripheral blood levels of novel inflammatory biomarkers were collected,including neutrophil-to-lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),monocyte to lymphocyte ratio(MLR),monocyte to high-density lipoprotein cholesterol ratio(MHR),and apolipoprotein B/apolipoprotein A1 ratio(Apo-B/Apo-A1).The differences in novel inflammatory biomarkers levels between the high-grade subgroup and the low-grade subgroup in AIS patients were compared.Logistic regression analysis was employed to identify the factors influencing the grade of neovascularization in carotid plaques.Receiver operating characteristic(ROC)curve analysis was conducted to analyze the diagnostic value of novel inflammatory biomarkers for high-grade subgroup in AIS patients.Results After balancing for gender,age,body mass index,and smoking index using covariance analysis,the levels of novel inflammatory biomarkers as Apo-B/Apo-A1,NLR,and MHR in AIS patients were significantly different between the high-grade and low-grade subgroups(P<0.05).Multivariate Logistic regression analysis showed that Apo-B/Apo-A1,MHR,and NLR were influencing factors of neovascularization grade of carotid plaques in AIS patients.The areas under the ROC curve(AUCs)of ApoB/ApoA1,MHR,NLR,and their combination for predicting high-grade subgroup in AIS patients were 0.776,0.650,0.615,and 0.802,respectively.The AUC of the combination was the largest,the sensitivity and specificity were 85.6%and 71.4%,respectively.Conclusion Apo-B/Apo-A1,NLR,and MHR are factors influencing carotid vulnerable plaques in AIS patients,the combined diagnostic value of these three parameters is relatively high.关键词
急性缺血性脑卒中/颈动脉斑块/新型炎症标志物/超微血管成像技术Key words
Acute ischemic stroke/Carotid plaque/Novel inflammatory biomarkers/Superb microvascular imaging引用本文复制引用
殷彤,戴佳盈,张树华,刘洋,唐姗,李宁..急性缺血性脑卒中患者外周血新型炎症标志物水平与颈动脉斑块易损性的相关性研究[J].心脑血管病防治,2025,25(10):11-14,23,5.基金项目
2020年唐山市科学技术研究与发展计划项目(20150207C) （20150207C）
河北省2025年政府资助临床医学优秀人才培养项目(ZF2025282) （ZF2025282）
