摘要
Abstract
Objective To investigate the correlation between serum bile acid level and the risk of cardiovascular events in patients with type 2 diabetes mellitus(T2DM).Methods A total of 212 T2DM patients admitted to Pangang Group General Hospital from January 2021 to May 2022 were selected.Baseline serum bile acid level at admission was determined,and patients were divided into a high-level group and a low-level group according to the median serum bile acid level,with 106 cases in each group.After 24 months follow-up,the risk of cardiovascular events was analyzed using the Kaplan-Meier model and compared using the Log-rank test.At the 24-month follow-up,99 cases in the high-level group and 102 cases in the low-level group completed the follow-up.Cardiovascular events occurred in 36 cases in the high-level group and 9 cases in the low-level group.Meanwhile,based on the occurrence of cardiovascular events,the patients were divided into a occurrence group(45 cases)and a non-occurrence group(156 cases),and the general data of the two groups was compared.A COX proportional hazards regression model was used to analyze factors associated with cardiovascular events in T2DM patients,and the relationship between serum bile acid level and cardiovascular events in T2DM patients was analyzed using the restricted cubic spline.Results The Log-rank test showed that the risk of cardiovascular events was higher in the high-level group than in the low-level group(Log-Rank χ2=6.111,P<0.05).The occurrence group showed significantly higher levels of diabetes duration,glycated hemoglobin(HbA1c),low-density lipoprotein(LDL),and bile acid compared to the non-occurrence group,with statistically significant differences(P<0.05).COX proportional hazards regression showed that diabetes duration,bile acid,HbA1c,and LDL were influencing factors for the occurrence of cardiovascular events.Restricted cubic spline showed a linear dose-response relationship between the serum bile acid level and the cardiovascular events in T2DM patients under the condition of controlled diabetes duration,HbA1c,and LDL(χ2=28.810,P<0.05).Conclusion Serum bile acid level is associated with the risk of cardiovascular events in T2DM patients,and may be used as a marker for the prediction of cardiovascular events in T2DM patients.关键词
血清胆汁酸/2型糖尿病/心血管事件Key words
Serum bile acid/Type 2 diabetes/Cardiovascular events
