心脑血管病防治2025，Vol.25Issue(10)：19-23,5.DOI:10.3969/j.issn.1009-816x.2025.10.005
血清层粘连蛋白、碱性磷酸酶、C肽对慢性心力衰竭患者心血管事件的预测价值
Predictive value of serum laminin,alkaline phosphatase,and C-peptide for cardiovascular events in patients with chronic heart failure
摘要
Abstract
Objective To investigate the predictive value of serum laminin(LN),alkaline phosphatase(ALP),and C-peptide for cardiovascular events in patients with chronic heart failure(CHF).Methods From January 2021 to January 2024,112 CHF patients diagnosed in the No.2 Hospital of Baoding were regarded as the observation group,and 77 healthy individuals who underwent physical check ups were regarded as the control group.According to the New York Heart Association(NYHA)functional classification,the observation group was assigned into the gradeⅡgroup(46 cases),gradeⅢ group(39 cases),and gradeⅣ group(27 cases).They were classified into a cardiovascular event group(44 cases)and a non-cardiovascular event group(68 cases)based on the occurrence of cardiovascular events during the 6-month follow-up period.The levels of serum LN,ALP,and C-peptide were detected.Logistic regression was applied to analyze the factors influencing cardiovascular events in CHF patients.Receiver operating characteristic(ROC)curves were applied to analyze the values of serum LN,ALP,and C-peptide levels in predicting cardiovascular events in CHF patients.Results Compared with the control group,the observation group showed significantly higher serum levels of LN and ALP and lower serum C-peptide level(P<0.05).The levels of serum LN and ALP in CHF patients increased with the increase of cardiac function grading,while the level of C-peptide decreased(P<0.05).Compared with the non-cardiovascular event group,the cardiovascular group showed significantly higher proportion of diabetes history,left ventricular end-diastolic dimension(LVEDD),left ventricular mass index(LVMI),N-terminal pro-B-type natriuretic peptide(NT-proBNP),LN,and ALP,along with lower left ventricular ejection fraction(LVEF)and C-peptide levels(P<0.05).Logistic regression analysis showed that diabetes history,LVEF,LVEDD,LVMI,and NT-proBNP were influencing factors for cardiovascular events in CHF patients(P<0.05).The area under the curve(AUC)values of serum LN,ALP,and C-peptide levels in predicting cardiovascular events in CHF patients were 0.863,0.855,and 0.872,respectively,which were obviously lower than the AUC value of combined prediction(0.949)(Z=2.288,2.335,2.097;P<0.05).Conclusion Serum levels of LN and ALP are significantly elevated and C-peptide level is reduced in CHF patients with cardiovascular events.They all change with the increase of functional grade,and their combined use has a good predictive efficacy for cardiovascular events in CHF patients.关键词
层粘连蛋白/碱性磷酸酶/C肽/慢性心力衰竭/预测价值Key words
Laminin/Alkaline phosphatase/C-peptide/Chronic heart failure/Predictive value引用本文复制引用
宫阳阳,宫丽丽,刘倩,宋岳涵,凡永军,张娜..血清层粘连蛋白、碱性磷酸酶、C肽对慢性心力衰竭患者心血管事件的预测价值[J].心脑血管病防治,2025,25(10):19-23,5.基金项目
保定市科技计划社发类项目(2141ZF010) （2141ZF010）
