湖北科技学院学报（医学版）2025，Vol.39Issue(6)：476-479,4.DOI:10.16751/j.cnki.2095-4646.2025040814
山奈酚缓解氧化应激改善自发性高血压大鼠肾纤维化
Kaempferol Alleviates Oxidative Stress and Improves Renal Fibrosis in Spontaneously Hypertensive Rats
摘要
Abstract
Objective To explore the mechanism by which kaempferol(Kae)ameliorates renal fibrosis in spontaneously hyperten-sive rats(SHR).Methods Rats were divided into four groups(n=8 per group):CON group,SHR group,SHR+Los(Losartan)group,and SHR+Kae group.The rats were administered the corresponding treatments by gavage twice daily(morning and evening)for four consecutive weeks.After that,blood pressure was measured and renal tissues were collected.Renal tissues were stained with H&E,PAS and DHE,and Western blot was used for detecting the expression of fibrosis-related proteins and NRF2 protein.Results Compared with the CON group,the renal tissues of the SHR group showed obvious fibrotic changes,increased ROS production,and significantly elevated expression of collagen-related proteins(P＜0.001),and significantly decreased expression of NRF2(P＜0.01).After Kae treatment,the blood pressure of rats decreased,renal fibrosis was significantly improved,ROS production was significantly reduced,and the expression of NRF2 increased.Con-clusion Kaempferol can improve renal fibrosis in spontaneously hypertensive rats by alleviating oxidative stress.关键词
山奈酚/高血压肾病/氧化应激/肾纤维化Key words
Kaempferol/Hypertensive nephropathy/Oxidative stress/Renal fibrosis分类
药学引用本文复制引用
蒋越,李奥迪,徐甲淇,赵纪接,陈清杰..山奈酚缓解氧化应激改善自发性高血压大鼠肾纤维化[J].湖北科技学院学报（医学版）,2025,39(6):476-479,4.基金项目
湖北省自然科学基金咸宁创新发展联合基金(2025AFD88) （2025AFD88）
