湖北科技学院学报（医学版）2025，Vol.39Issue(6)：480-483,4.DOI:10.16751/j.cnki.2095-4646.2025040908
雷公藤红素对糖尿病大鼠皮层的保护作用研究
Study on the Protective Effect of Celastrol on the Cortex of Diabetic Rats
摘要
Abstract
Objective To investigate the protective effect of Celastrol(CEL)on the cerebral cortex of diabetic rats.Methods A rat model of diabetes mellitus(DM)was established by combining a high-fat diet with an intraperitoneal injection of streptozotocin(STZ,35mg/kg).The treatment group was administered CEL(4mg/kg/day)orally for 12 weeks.The conditioned fear experiment was used to as-sess the rats' learning and memory abilities.Nissl staining was performed to examine the morphology and number of cortical neurons.Immu-nofluorescence was used to detect the expression level of p-NF-κB in the cerebral cortex.Western blot analysis was conducted to measure the expression of p38AMPK and STAT3 proteins.Results Compared with the DM group,the CEL-treated rats showed more orderly arrangement,regular morphology of cortical neurons,with no significant cell vacuolation.Additionally,the number of Nissl bodies was increased,p-NF-κB expression was reduced,and the expression of p38AMPK and STAT3 proteins were downregulated.Conclusion CEL exerts a protective effect on the cerebral cortex of DM rats and improves learning and memory abilities,which may be related to the p38AMPK/STAT3 signaling path-way.关键词
雷公藤红素/糖尿病/大脑皮层/认知功能/p38AMPK/STAT3Key words
Celastrol/Diabetes/Cerebral cortex/Cognitive function/p38AMPK/STAT3分类
医药卫生引用本文复制引用
黄静,刘晓姗,雷敏,郭西英..雷公藤红素对糖尿病大鼠皮层的保护作用研究[J].湖北科技学院学报（医学版）,2025,39(6):480-483,4.基金项目
湖北省科技计划项目(2021DFE025) （2021DFE025）
湖北省教育厅项目(BXLBX0808) （BXLBX0808）
