湖北科技学院学报（医学版）2025，Vol.39Issue(6)：494-498,5.DOI:10.16751/j.cnki.2095-4646.2025031206
基于响应面法优化虎杖苷巴布剂的处方
Optimization of the Prescription of Polydatin Cataplasm Based on Response Surface Method
摘要
Abstract
Objective To optimize the preparation of polydatin cataplasm by response surface methodology.Methods Physical and sensory evaluations were used as indicators to assess the performance of the patch.The Plackett-Burman screening design was employed to i-dentify significant factors affecting the formulation,followed by optimization using the Box-Behnken response surface methodology.Results The Plackett-Burman screening identified carbomer,sodium poly acrylate,and polyethylene glycol 400 as significant factors.The optimal for-mulation ratio determined by the Box-Behnken design was carbomer∶polyethylene glycol 400∶sodium polyacrylate∶aluminum hydroxyglyci-nate∶glycerin∶tartaric acid∶laurocapram∶polydatin=11∶127∶90∶7∶30∶1∶27∶10.The prepared patch exhibited excellent overall perform-ance,with moderate initial adhesion and no skin residue.Conclusion This study successfully optimized the matrix composition of the polyda-tin plaster using response surface methodology,resulting in a formulation with high stability,thereby offering a novel strategy for the transder-mal drug delivery systems of traditional Chinese medicine.关键词
虎杖苷/巴布贴剂/响应面法/Plackett-Burman筛选设计Key words
Polydatin/Cataplasms/Response surface methodology/Plackett-Burman screening design分类
药学引用本文复制引用
徐梓豪,姚嘉伦,李寺玉,胡宗杰,符泰铭,王家豪,余薇,闵清,要辉..基于响应面法优化虎杖苷巴布剂的处方[J].湖北科技学院学报（医学版）,2025,39(6):494-498,5.基金项目
大学生创新训练项目(S202210927037) （S202210927037）
