烟草科技2025，Vol.58Issue(11)：14-25,12.DOI:10.16135/j.issn1002-0861.2025.0325
反吹系统耦合GC-MS-MS测定卷烟主流烟气中35种有机硫化物
Determination of 35 organic sulfides in mainstream cigarette smoke using a blowback system coupled with GC-MS-MS
摘要
Abstract
To determine the trace organic sulfides in mainstream cigarette smoke with high accuracy,a simultaneous analytical method was developed using a blowback system coupled with gas chromatography-tandem mass spectrometry(GC-MS-MS)to quantify 35 potential organic sulfides in mainstream cigarette smoke,with optimized pretreatment conditions and the time of blowback in the instrumental parameters.This method was then used to analyze the releases of 35 organic sulfides in 32 Virginia type and 6 blended type cigarette samples and the differences among them.The results showed that:1)The introduction of the blowback system significantly reduced the retention of high boiling point components in the chromatographic separation columns,lowered the risk of cross contamination across samples,and enhanced the retention time consistency during continuous injections.2)A total of 25 organic sulfides were detected in mainstream smoke of the cigarette samples,and 19 of which were identified in all the samples.The results of principal component analysis(PCA)showed that there was clear distinction between the two types of cigarettes.Heatmap analysis and t-test results revealed that the average releases per unit tar of thiophene,thiazole,furfuryl mercaptan,tetrahydrothiophen-3-one,2-acetylthiazole,4-methyl-5-vinylthiazole,5-methylthiophene-2-carboxaldehyde and 5-(2-hydroxyethyl)-4-methylthiazole were significantly higher in mainstream smoke of blended type cigarettes than those in Virginia type cigarettes(p<0.01),while the average release per unit tar of 4-(methylthio)butyronitrile in mainstream smoke of Virginia type cigarettes was 2.9 times of that in blended cigarettes(p<0.01).3)Six organic sulfides were detected only in mainstream smoke of some cigarette samples,with the detection rates of methyl 2-thiofuroate and 2-methyl-3-methylthiopyrazine in mainstream smoke of blended cigarette samples reached 67%and 83%respectively,and those of furfuryl methyl disulfide,dibutyl sulfide,8-mercaptomenthone and difurfuryl sulfide in mainstream smoke of cigarette samples were no more than 40%.关键词
卷烟/主流烟气/有机硫化物/串联质谱/固相萃取Key words
Cigarette/Mainstream smoke/Organic sulfide/Tandem mass spectrometry/Solid phase extraction分类
轻工业引用本文复制引用
陈志燕,秦亚琼,李志华,王晓瑜,范忠,周芸,严俊..反吹系统耦合GC-MS-MS测定卷烟主流烟气中35种有机硫化物[J].烟草科技,2025,58(11):14-25,12.基金项目
中国烟草总公司科技计划项目"基于风味组学和分子对接的烟气甜感关键成分组群研究"(110202403007) （110202403007）
广西中烟工业有限责任公司科技项目"卷烟烟气甜感物质基础研究"(GXZYCX2023C010). （GXZYCX2023C010）
