疑难病杂志2025，Vol.24Issue(11)：1302-1307,6.DOI:10.3969/j.issn.1671-6450.2025.11.005
肺腺癌组织中LAMTOR1、RGS20表达与患者临床病理特征的相关性分析及预后价值
The correlation between the expression of LAMTOR1 and RGS20 in lung adenocarcinoma tissues and the clinicopath-ological features and the prognostic value
摘要
Abstract
Objective To investigate the relationship between the expression of late endosomal/lysosomal adaptor,MAPK and MTOR activator 1(LAMTOR1),regulator of G-protein signaling 20(RGS20)and clinicopathological features and prognosis in advanced lung adenocarcinoma.Methods The clinical data of 144 patients with NSCLC admitted to the Depart-ment of Respiratory Medicine of the First Affiliated Hospital of Xinjiang Medical University from January 2020 to January 2022 were collected.The expressions of LAMTOR1 mRNA,RGS20 mRNA and protein were detected by qPCR and immuno-histochemistry.Kaplan-Meier survival analysis and Cox proportional hazard regression model were used to evaluate the effect of LAMTOR1 and RGS20 expression on patient prognosis.Results The expressions of LAMTOR1 and RGS20 mRNA in lung adenocarcinoma tissues were(2.34±0.56)and(2.63±0.67),which were higher than those in adjacent tissues(0.84±0.26)and(0.74±0.16)(t=29.154,32.925,all P＜0.001).The positive rate of LAMTOR1 in cancer tissues was 70.83％(102/144),which was higher than that in adjacent tissues 5.56％(8/144)(x2=129.968,P＜0.001);the positive rate of RGS20 in cancer tissues was 63.89％(96/144),which was higher than that in adjacent tissues 6.94％(10/144)(x2=110.411,P＜0.001).The positive rates of LAMTOR1 and RGS20 were higher in patients with TNM stage Ⅲ A than in those with TNM stage Ⅰ-Ⅱ,and higher in patients with lymph node metastasis than in those without lymph node metastasis(x2=10.980,6.534,13.333,10.800;P=0.001,0.011,＜0.001,0.001).TNM stage ⅢA,lymph node metastasis,LAMTOR1 positive and RGS20 positive were risk factors for poor prognosis in patients with lung adenocarcinoma[HR(95％CI)=1.344(1.099-1.645),1.305(1.074-1.584),1.363(1.046-1.776),1.354(1.087-1.686)].Conclusion LAMTOR1 and RGS20 are highly expressed in lung adenocarcinoma,which is associated with poor clinicopathological features and can serve as potential prognostic bio-markers.关键词
肺腺癌/晚期内体/溶酶体适配蛋白1/G蛋白信号通路调节蛋白20/预后Key words
Lung adenocarcinoma/Late endosome/lysosome adapter protein 1/Regulator of G-protein signaling 20/Prognosis分类
医药卫生引用本文复制引用
李晗,赵伟,如斯坦木·牙森,龚新记,郝艳艳,克丽别娜·吐尔逊..肺腺癌组织中LAMTOR1、RGS20表达与患者临床病理特征的相关性分析及预后价值[J].疑难病杂志,2025,24(11):1302-1307,6.基金项目
新疆维吾尔自治区自然科学基金(2022D01C231) Natural Science Foundation of Xinjiang Uygur Autonomous Region(2022D01C231) （2022D01C231）
