疑难病杂志2025，Vol.24Issue(11)：1308-1312,5.DOI:10.3969/j.issn.1671-6450.2025.11.006
肝细胞肝癌组织中PGAM1、ASS1表达及其与患者临床预后价值分析
The expression of PGAM1 and ASS1 in hepatocellular carcinoma tissue and clinical prognostic value
摘要
Abstract
Objective To investigate the expression of phosphoglycerate mutase 1(PGAM1)and arginine succinate synthase 1(ASS1)in hepatocellular carcinoma(HCC)tissues and explore their prognostic significance.Methods Tissue spec-imens and clinical data of 124 HCC patients treated in the Department of Hepatobiliary Pancreatic Hernia Surgery,Affiliated Hospital of Xuzhou Medical University from January 2020 to January 2022 were collected.The expression of PGAM1 and ASS1 proteins in HCC was detected by immunohistochemistry.The differential expression of PGAM1 and ASS1 proteins in cancer tissues of HCC patients with different clinical features was compared.Kaplan-Meier curve and Cox regression analysis were used to investigate the prognostic factors of HCC.Results The positivity rate of PGAM1 in HCC cancer tissues was higher than that in adjacent tissues(66.13％vs.8.06％),while the positivity rate of ASS1 was lower than that in adjacent tis-sues(33.06％vs.87.10％),with statistical significance(x2=89.579,75.471,P＜0.00l).The expression of PGAM1 and ASS1 proteins in HCC cancer tissues was negatively correlated(rs=-0.795,P＜0.001).The positivity rate of PGAM1 protein in cancer tissues was higher in CNLC stages Ⅱ-Ⅲ than in stage Ⅰ,and the positivity rate of ASS1 protein in cancer tissues with CNLC stages Ⅱ-Ⅲ was lower than in stage Ⅰ(x2/P=22.689/＜0.001,6.933/0.008).The overall 3-year survival rates of PGAM1 positive and negative groups were 43.90％(36/82)and 76.19％(32/42),respectively,with a statistically significant difference between the curves(Log-rank x2=13.440,P＜0.001).The overall 3-year survival rates of ASS1 positive and negative groups were 82.93％(34/41)and 41.98％(34/81),respectively,with statistically significant differences between the curves(Log-rank x2=19.280,P＜0.001).CNLC stage Ⅱ-Ⅲ and PGAM1 positivity were risk factors affecting the prognosis of HCC,while ASS1 positivity was a protective factor[HR(95％CI)=1.602(1.175-2.183),1.684(1.228-2.308),0.635(0.484-0.834)].Conclusion The upregulation of PGAM1 expression and downregulation of ASS1 expression in HCC are associated with CNLC staging and are potential tumor markers for evaluating the prognosis of HCC patients.关键词
肝细胞肝癌/磷酸甘油酸变位酶1/精氨酸琥珀酸合成酶1/预后/临床意义Key words
Hepatocellular carcinoma/Phosphoglycerate mutase 1/Argininosuccinate synthase 1/Prognosis/Clinical significance分类
临床医学引用本文复制引用
赵明明,杨勇,吴超,杨军..肝细胞肝癌组织中PGAM1、ASS1表达及其与患者临床预后价值分析[J].疑难病杂志,2025,24(11):1308-1312,5.基金项目
江苏省卫生健康委医学科研项目(H2023168) Medical Research Project of Jiangsu Provincial Health Commission(H2023168) （H2023168）
