疑难病杂志2025，Vol.24Issue(11)：1313-1317,5.DOI:10.3969/j.issn.1671-6450.2025.11.007
胰腺癌患者血清TNC、BPTF表达水平及其对生存预后的评估价值
The expression levels of serum TNC and BPTF in patients with pancreatic cancer and their evaluation value for sur-vival prognosis
摘要
Abstract
Objective To investigate the expression and prognostic value of serum tenascin C(TNC)and bromo-domain PHD-finger transcription factor(BPTF)in patients with pancreatic cancer.Methods A total of 102 patients with pan-creatic cancer diagnosed and treated in the Department of Gastroenterology,Heilongjiang Provincial Hospital from January 2020 to January 2022 were selected as the pancreatic cancer group,and 60 healthy subjects were selected as the healthy con-trol group.Serum TNC and BPTF levels were measured by enzyme-linked immunosorbent assay.The expression levels of ser-um TNC and BPTF in pancreatic cancer patients with different clinicopathological parameters were compared.The prognostic value of serum TNC and BPTF levels was evaluated using receiver operating characteristic(ROC)curve analysis.Kaplan-Meier survival curves and Cox regression were used to analyze the relationship between serum TNC,BPTF levels and progno-sis in pancreatic cancer patients.Results Serum TNC and BPTF levels in pancreatic cancer patients were significantly higher than those in healthy controls(t/P=34.850/＜0.001,26.931/＜0.001).Patients with tumor stages Ⅱ B-Ⅲ and lymph node metas-tasis showed higher serum TNC and BPTF levels compared to those with stages Ⅰ-ⅡA and no lymph node metastasis(TNC:t/P=16.041/＜0.001,11.132/＜0.001;BPTF:t/P=16.377/＜0.001,11.416/＜0.001).The AUC values of serum TNC,BPTF,and their combination for predicting pancreatic cancer prognosis were 0.862,0.846,and 0.921,respectively.The combined predic-tive value was superior to that of either biomarker alone(Z/P=4.551/＜0.001,4.558/＜0.001).The 3-year overall survival rate in the TNC high-expression subgroup was lower than that in the TNC low-expression subgroup(Log-rank x2=16.120,P＜0.001),and the 3-year overall survival rate in the BPTF high-expression subgroup was lower than that in the BPTF low-expression subgroup(Log-rank x2=13.380,P＜0.001).Tumor stage Ⅱ B-Ⅲ,lymph node metastasis,high TNC expression,and high BPTF expression were identified as independent risk factors for prognosis in pancreatic cancer patients[OR(95％CI)=1.774(1.217-2.584),1.587(1.272-1.981),1.404(1.140-1.728),1.507(1.150-1.975)].Conclusion Elevated serum TNC and BPTF levels in pancreatic cancer are associated with tumor stage and lymph node metastasis.The combination of TNC and BPTF demonstrates good predictive value for the prognosis of pancreatic cancer patients.关键词
胰腺癌/人肌腱蛋白C/溴区结构域转录因子/生存预后Key words
Pancreatic Cancer/Tenascin C/Bromodomain transcription factors/Survival prognosis分类
医药卫生引用本文复制引用
奚腾飞,宋玮佳,张景淳,蒋博睿,唐丽欣..胰腺癌患者血清TNC、BPTF表达水平及其对生存预后的评估价值[J].疑难病杂志,2025,24(11):1313-1317,5.基金项目
黑龙江省自然科学基金(LH2023H086) Natural Science Foundation of Heilongjiang Province(LH2023H086) （LH2023H086）
