疑难病杂志2025，Vol.24Issue(11)：1318-1322,5.DOI:10.3969/j.issn.1671-6450.2025.11.008
胰腺癌组织SOX7、ZEB1表达与临床病理特征及预后的关系
Expression of SOX7 and ZEB1 in pancreatic cancer and their relationship with prognosis
摘要
Abstract
Objective To analyze the expression levels of SRY box-related gene 7(SOX7)and zinc finger E-box binding protein 1(ZEB1)in pancreatic cancer tissues and their relationship with patient prognosis.Methods A total of 115 patients with pancreatic cancer admitted to the Department of Hepatobiliary Surgery,East Campus,Jinan Central Hospital from January 2021 to April 2022 were included in the study.During surgery,both cancerous and adjacent tissues were resected from the patients,and the expression levels of SOX7 and ZEB1 proteins in the tissues were detected by immunohistochemistry.Pa-tient pathological characteristics were collected.The patients were followed up for 3 years,during which 48 patients survived and 67 patients died.Multivariate Cox regression analysis was performed to identify prognostic factors.The relationship be-tween SOX7 and ZEB1 expression levels and prognosis was analyzed using the Kaplan-Meier method.Results Compared with adjacent tissues,the positive expression rate of SOX7 in cancer tissues decreased,while the positive expression rate of ZEB1 increased(x2/P=28.186/＜0.001).Compared with pancreatic cancer patients without lymph node metastasis,with stage Ⅰtumors,and invasion depth of Tis-T2,the positive expression rate of SOX7 in patients with lymph node metastasis,stage Ⅲtumors,and invasion depth of T3-4 was decreased(x2/P=4.973,9.534,45.083/0.026,0.009,＜0.001),while the positive ex-pression rate of ZEB1 increased(x2/P=7.547,40.573,7.952/0.006,＜0.001,0.005).The 3-year survival rate of patients with positive SOX7 expression(36/44,81.82％)was higher than that of patients with negative SOX7 expression(12/71,16.90％)(x2=47.077,P＜0.001).The 3-year survival rate of patients with positive ZEB1 expression(31/95,32.63％)was lower than that of patients with negative ZEB1 expression(17/20,85.00％)(x2=18.633,P＜0.001).Positive expression of ZEB1 was identified as a risk factor for death in pancreatic cancer patients,while positive expression of SOX7 was a protective factor[HR(95％ CI)=0.409(0.282-0.592),2.341(1.655-3.312)].Conclusion The positive rate of SOX7 is decreased and that of ZEB1 is increased in pancreatic cancer.Changes in the expression of both are closely related to patient prognosis.关键词
胰腺癌/组织SRY盒相关基因7/锌指E盒结合蛋白1/临床病理特征/预后Key words
Pancreatic cancer/SRY-box containing gene 7/Zinc finger E-box binding homeobox protein 1/Clinical pathological features/Prognosis分类
临床医学引用本文复制引用
郝法涛,李俭银,孟勇,王翔宇,于万迎..胰腺癌组织SOX7、ZEB1表达与临床病理特征及预后的关系[J].疑难病杂志,2025,24(11):1318-1322,5.基金项目
济南市2023年卫健委科技计划项目(2023-1-16) Jinan Municipal Health Commission Science and Technology Plan Project(2023-1-16) （2023-1-16）
