疑难病杂志2025，Vol.24Issue(11)：1341-1346,6.DOI:10.3969/j.issn.1671-6450.2025.11.012
血清HSP27、omentin-1、CC16水平在评估脓毒症休克患者病情严重程度及不良预后中的价值分析
The relationship between serum HSP27,Omentin-1,CC16 levels and severity of septic shock patients and ROC analysis for predicting adverse prognosis
摘要
Abstract
Objective To explore the relationship between serum heat shock protein 27(HSP27),omentin-1,Clara cell secreted protein 16(CC16)and the severity of septic shock patients,and to predict adverse prognosis using ROC analysis.Methods From April 2022 to March 2025,205 sepsis patients in Southern Hospital of the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University were enrolled as the observation group.They were divided into a sepsis group(n=108)and a septic shock(SK)group(n=97)based on disease severity.According to the 28-day survival status,SK patients were further divided into a survival subgroup(n=56)and a death subgroup(n=41).Meanwhile,100 healthy individuals undergoing physi-cal examinations at our hospital served as the healthy control group.ELISA was used to measure serum HSP27,omentin-1,and CC16 levels,and differences were compared among the groups.Relative risk(RR)analysis was applied to evaluate the impact of different levels of HSP27,omentin-1,and CC16 on the prognosis and survival of SK patients.ROC analysis was used to assess the predictive value of HSP27,omentin-1,CC16,and their combination for adverse prognosis in SK.Results The observation group showed higher serum HSP27,omentin-1,and CC16 levels than the healthy control group(t/P=46.391/＜0.001,12.406/＜0.001,27.184/＜0.001).Compared with the sepsis group,the SK group had higher serum HSP27,omentin-1,and CC16 levels(t/P=6.191/＜0.001,5.981/＜0.001,5.249/＜0.001).The death subgroup exhibited higher serum HSP27,omentin-1,and CC16 levels than the survival subgroup(t/P=47.905/＜0.001,6.214/＜0.001,18.517/＜0.001).The risk of adverse prognosis in SK patients with high levels of serum HSP27,omentin-1,and CC16 was 2.264,2.796,and 2.025 times higher than in those with low levels,respectively(x2/P=9.840/0.002,15.110/＜0.001,7.974/0.005).The AUC values of serum HSP27,omentin-1,CC16,and their combination for predicting poor prognosis in SK patients were 0.860,0.864,0.886,and 0.965,respectively.The combined prediction of all three markers was superior to the AUC of each individual prediction(Z=2.823,2.715,2.386;P=0.005,0.007,0.017).Conclusion Serum HSP27,omentin-1,and CC16 levels are closely related to the condition and prognosis of SK patients.ROC analysis indicates that combined detection has higher predictive value,may serve as potential biomarkers for predicting adverse prognosis in SK patients,and is beneficial for clinical evaluation of disease severity and prognosis.关键词
脓毒症休克/热休克蛋白27/网膜素-1/Clara细胞分泌蛋白16/预后/病情程度Key words
Septic shock/Heat shock protein 27/Omentin-1/Clara cell secreted protein 16/Prognosis/Severity分类
临床医学引用本文复制引用
郑从波,胡芳宝,王文,窦红杰,林凌,王德强..血清HSP27、omentin-1、CC16水平在评估脓毒症休克患者病情严重程度及不良预后中的价值分析[J].疑难病杂志,2025,24(11):1341-1346,6.基金项目
上海市奉贤区科委科技发展基金项目(奉科20221401) Science and Technology Development Fund Project of Fengxian District Science and Technology Commission,Shanghai(Fengke 20221401) （奉科20221401）
