空军军医大学学报2025，Vol.46Issue(11)：1409-1414,6.DOI:10.13276/j.issn.2097-1656.2025.11.002
从误判到确证:盐酸甲氟喹绝对构型四十年的科学认知纠错及其对军事药物研发的启示
From misjudgment to confirmation:a four-decade revision of absolute configuration of mefloquine hydrochloride and its implications for military pharmaceutical research
摘要
Abstract
Mefloquine hydrochloride is a critically important antimalarial agent with strategic significance for military overseas operations.Nevertheless,the absolute configuration of its stereoisomers remained controversial for decades.Early studies erroneously assigned the(+)-erythro enantiomer as(11R,12S),leading to extensive subsequent research being based on an incorrect structural foundation.Systematic review reveals that this misassignment stemmed from technical limitations and cognitive biases,while modern chiral synthesis and single-crystal X-ray diffraction ultimately provided unequivocal confirmation.Reflecting on the characteristics of military-specific drug development,this case underscores the necessity of accurate structural elucidation for chiral drugs,the pivotal role of technological advancement,and the imperative of critical thinking in military pharmaceutical research.关键词
甲氟喹/立体异构现象/手性/分子结构/晶体学/药物开发/军事医学/制药Key words
mefloquine/stereoisomerism/chirality/molecular structure/crystallography/drug development/military medicine/pharmaceutical分类
特种医学引用本文复制引用
周钢,魏朝,聂慧芳,李穆琼,席佳越,王平安..从误判到确证:盐酸甲氟喹绝对构型四十年的科学认知纠错及其对军事药物研发的启示[J].空军军医大学学报,2025,46(11):1409-1414,6.基金项目
国家自然科学基金青年科学基金(8240131756) （8240131756）
