空军军医大学学报2025，Vol.46Issue(11)：1421-1424,1432,5.DOI:10.13276/j.issn.2097-1656.2025.11.004
高温环境下3种战救药品注射液的稳定性研究
Stability study of three injectable combat medicines under high-temperature conditions
摘要
Abstract
Objective To provide rational recommendations for the storage and management of combat medicines by medical units,and thus to enhance medical support effectiveness through investigating the stability changes of the medicines under high-temperature conditions of military operations.Methods The selected medicines were respectively placed in high-temperature conditions of 35,45 and 55 ℃.Samples were collected at indicated time points,and the content was determined by high-performance liquid chromatography.Results Lidocaine hydrochloride injection and tranexamic acid injection demonstrated good stability at 35,45 and 55 ℃,with content measurements meeting the required standards.Dopamine hydrochloride injection maintained acceptable content levels at 35,45 and 55 ℃,but impurity peaks occurred.Conclusion Current storage of combat medicines still requires strict adherence to established protocols.The stability of these medicines is insufficient to fully meet the demands of military medical support.In the future,guidance protocols for the stability of combat medicines under specific military environmental conditions should be developed to improve the effectiveness of pharmaceutical support provided by medical units operating in field conditions.关键词
战救药品/高温环境/药品稳定性/卫勤保障/注射液/高效液相色谱法/药物含量/药品储存Key words
combat medicines/high-temperature conditions/drug stability/medical support/injections/high-performance liquid chromatography/drug content/drug storage分类
特种医学引用本文复制引用
王伟,朱艳荣,关舒心,辛春艳,王宇翔,李晨,葛煦..高温环境下3种战救药品注射液的稳定性研究[J].空军军医大学学报,2025,46(11):1421-1424,1432,5.基金项目
陕西省重点研发计划项目(2021SF-112) （2021SF-112）
空军军医大学"临床医学+X"研究中心科研课题(LHJJ24YX20) （LHJJ24YX20）
空军军医大学航空医学重点问题科技攻关项目(2024GJJH03-04) （2024GJJH03-04）
