摘要
Abstract
Objective To identify factors associated with new-onset atrial fibrillation(NOAF)in patients with sepsis.Methods This retrospective study included 160 patients with sepsis treated at the Second Affiliated Hospital of Zhengzhou University from January 2022 to December 2024.Based on clinical outcomes,patients were assigned to a study group(sepsis with NOAF)and a control group(sepsis without NOAF),80 cases each.General clinical characteristics and sepsis-related indices were analyzed,including organ dysfunction,illness severity,medication use,and laboratory parameters.Variables with significant differences in univariate analysis were entered into a multivariable logistic regression model to evaluate factors associated with NOAF.Results Univariate analysis showed that,among general characteristics,age was significantly higher in the study group than in the control group(P＜0.05),while sex,length of hospital stay,baseline comorbidities,and duration of mechanical ventilation did not differ significantly(P＞0.05).Regarding clinical indices,the study group had higher rates of organ dysfunction(acute kidney injury,electrolyte disturbance,and coagulopathy),higher illness-severity scores[Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)and Sequential Organ Failure Assessment(SOFA)],greater use of theophylline-class medications,and longer prothrombin time than the control group(P＜0.05).No significant differences were observed for other organ dysfunctions,medication exposures,or laboratory indices(P＞0.05).In multivariable logistic regression with NOAF occurrence as the dependent variable,age,APACHE Ⅱ score,and theophylline-class medications were identified as factors associated with NOAF(P＜0.05).Conclusion In patients with sepsis,older age,higher APACHE Ⅱ score,and use of theophylline-class medications are associated with an increased risk of new-onset NOAF.Early prevention and management targeting these factors may help reduce NOAF occurrence in sepsis.关键词
脓毒症/新发心房颤动/影响因素/多因素logistic回归模型Key words
sepsis/new-onset atrial fibrillation/associated factors/multivariable logistic regression model分类
临床医学
