Abstract
Objective To analyze factors associated with short-term mortality in sepsis-associated acute kidney injury(SA-AKI)and to evaluate their predictive performance.Methods This retrospective study included 68 patients with SA-AKI who were admitted to The First People's Hospital of Pingdingshan from February 2023 to December 2024.The patients were divided into a survivor group(n=39)and a non-survivor group(n=29)according to 28-day mortality after diagnosis.Factors associated with short-term mortality were analyzed.Results There were no statistically significant differences between the two groups in white blood cell count(WBC),procalcitonin(PCT),serum creatinine(SCr),UREA,uric acid(UA),β2-microglobulin(β2-MG),thrombin time(TT),fibrinogen(FIB),or D-dimer(DD)(P＞0.05).The Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score,Sequential Organ Failure Assessment(SOFA)score,C-reactive protein(CRP),lactic acid(LAC),retinol-binding protein(RBP),cystatin C(CysC),prothrombin time(PT),and activated partial thromboplastin time(APTT)in the survivor group were significantly lower than those in the non-survivor group(P＜0.05).Multivariate analysis of variables with significant differences showed that the APACHE Ⅱ score,SOFA score,CRP,LAC,RBP,CysC,PT,and APTT were independent factors associated with death in patients with SA-AKI(P＜0.05).Receiver operating characteristic(ROC)curve analysis indicated that the area under the ROC curve(AUC)for predicting mortality from SA-AKI were 0.704,0.809,0.832,0.709,0.702,0.778,0.794,0.742 and 0.962 for the APACHE Ⅱ score,SOFA score,CRP,LAC,RBP,CysC,PT,APTT and the combined testing.Conclusion The APACHE Ⅱ score,SOFA score,CRP,LAC,RBP,CysC,PT,and APTT are closely related to the prognosis of SA-AKI and are independent factors associated with mortality in patients with SA-AKI.Moreover,combined testing of multiple indicators has high predictive value.关键词
脓毒症/急性肾损伤/预后/相关性Key words
sepsis/acute kidney injury/prognosis/correlation分类
医药卫生
