摘要
Abstract
Objective To analyze the predictive value of fibrinogen degradation products(FDP),the lymphocyte-to-monocyte ratio(LMR),and the neutrophil-to-lymphocyte ratio(NLR)for poor prognosis in intensive care unit(ICU)patients with sepsis.Methods A total of 266 patients with sepsis admitted to Luoyang Dongfang People's Hospital between January 2022 and January 2024 were included.According to clinical outcomes,patients were classified into a poor-prognosis group(n=34)and a good-prognosis group(n=232).Levels of FDP,LMR,and NLR were compared between groups.Receiver operating characteristic(ROC)curves were used to evaluate the predictive performance for poor prognosis.Variables showing between-group differences were entered into logistic regression to identify factors associated with prognosis.Results The poor-prognosis group had higher FDP,neutrophil count(NEUT),and NLR and lower lymphocyte count(LYMPH)and LMR than the good-prognosis group,with statistically significant differences(P＜0.05).Logistic regression indicated that FDP,NLR,and LMR were independent factors associated with poor prognosis in patients with sepsis(P＜0.05).The areas under the ROC curve(AUCs)for NLR,FDP,LMR,and their combination were 0.735,0.815,0.850,and 0.915,respectively.Conclusion The combined assessment of FDP,NLR,and LMR has value for predicting poor prognosis in patients with sepsis and may guide early risk stratification.关键词
纤维蛋白原降解产物/淋巴细胞与单核细胞比值/脓毒症/中性粒细胞与淋巴细胞比值Key words
fibrinogen degradation products/lymphocyte-to-monocyte ratio/sepsis/neutrophil-to-lymphocyte ratio分类
医药卫生
