摘要
Abstract
Objective To analyze the clinical efficacy of quetiapine combined with sertraline in the treatment of pediatric depressive disorder.Methods A total of 92 children with depressive disorder(age＞6 and＜13 years)treated at Zhengzhou Eighth People's Hospital from January 2023 to December 2024 were enrolled and randomly assigned by the random-number table method to a control group(n=46)and an observation group(n=46).Both groups received sertraline hydrochloride tablets;on this basis,the observation group additionally received quetiapine fumarate tablets.The treatment duration for both groups was 3 months.Changes in indicators at admission and after treatment were compared.Depressive symptoms were assessed with the Children's Depression Inventory(CDI),and dysfunctional attitudes were assessed with the Dysfunctional Attitude Scale for Children(DAS-C).A fully automated immunoassay analyzer was used to measure four neurotransmitters—5-hydroxytryptamine(5-HT),dopamine(DA),substance P(SP),and neuropeptide Y(NPY).The incidences of adverse reactions(dizziness,dry mouth,somnolence,fatigue)during treatment were recorded.Results There were no statistically significant differences between the two groups in age,sex,height,weight,family situation,or family history of psychiatric disorders(P＞0.05).After treatment,CDI scores,DAS-C scores,and SP levels decreased compared with baseline in both groups,whereas 5-HT,DA,and NPY levels increased.Moreover,the observation group had lower CDI scores,DAS-C scores,and SP levels,and higher 5-HT,DA,and NPY levels than the control group,with statistically significant differences(P＜0.05).The incidence of adverse reactions did not differ significantly between the two groups(P＞0.05).Conclusion Quetiapine combined with sertraline can effectively improve depressive symptoms and dysfunctional attitudes in children,modulate neurotransmitter expression,and has a good safety profile.关键词
儿童抑郁障碍/喹硫平/舍曲林/功能失调性/神经递质Key words
pediatric depressive disorder/quetiapine/sertraline/dysfunctional attitudes/neurotransmitters分类
临床医学
