局解手术学杂志2025，Vol.34Issue(11)：977-980,4.DOI:10.11659/jjssx.01E025121
艾司氯胺酮预处理在儿童腹腔镜下疝囊高位结扎术中的应用效果
Application effect of esketamine pretreatment in laparoscopic high ligation of hernia sac in children
摘要
Abstract
Objective To determine the application effect of esketamine pretreatment in laparoscopic high ligation of hernia sac in children.Methods A total of 70 children who received laparoscopic high ligation of hernia sac under general anesthesia were selected and divided into the control group and the observation group according to the random number table method,with 35 cases in each group.The control group received conventional general anesthesia,while the observation group was intravenously injected with 0.5 mg/kg of esketamine 15 minutes before the induction of general anesthesia.The preoperative anxiety score,respiratory mechanics indexes,lung injury status,anesthesia recovery,and adverse reactions during the awakening period were compared between the two groups.Results The anxiety scores of the observation group 10 minutes before anesthesia and immediately before anesthesia were significantly lower than those of the control group(P<0.05).The peak airway pressure and mean airway pressure of the observation group 30 minutes after establishing pneumoperitoneum and at the end of the operation were significantly lower than those of the control group(P<0.05).The levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)at the end of the operation in the observation group were significantly lower than those in the control group(P<0.05).There was no statistically significant difference in the time of spontaneous breathing recovery,time to regain consciousness,tracheal extubation time,or post-anesthesia care unit(PACU)stay time between the two groups(P>0.05).The incidence of adverse reactions during the anesthetic awakening period in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Esketamine pretreatment can significantly alleviate preoperative separation anxiety for children undergoing laparoscopic high ligation of hernia sac,reduce lung injury,and decrease airway pressure,which is beneficial to lung protection and postoperative anesthetic recovery,and has few adverse reactions.关键词
艾司氯胺酮/腹腔镜手术/疝囊高位结扎术/焦虑情绪/肺损伤/术后恢复Key words
esketamine/laparoscopic surgery/high ligation of hernia sac/anxiety/lung injury/postoperative recovery分类
临床医学引用本文复制引用
周巧林,徐小艳,陶凤禹,石教辉,朱其飞,汪涛..艾司氯胺酮预处理在儿童腹腔镜下疝囊高位结扎术中的应用效果[J].局解手术学杂志,2025,34(11):977-980,4.基金项目
江苏省高校重点实验室开放课题资助项目(XZSYSKF2023010) （XZSYSKF2023010）
