中国康复2025，Vol.40Issue(11)：660-664,5.DOI:10.3870/zgkf.2025.11.004
右颞顶交界区低频经颅磁刺激对孤独症儿童刻板行为的影响
Effects of low-frequency transcranial magnetic stimulation of right temporoparietal junction on stereotyped behavior in autistic children
摘要
Abstract
Objective:To investigate the regulatory effects of low frequency repetitive transcranial magnetic stimu-lation(LF-rTMS)targeting right temporoparietal junction(rTPJ)on core symptoms,stereotyped behavior and resting state theta band power spectral density(PSD)in children with autism spectrum disorder(ASD).Methods:A randomized controlled design was adopted.A total of 70 children with ASD admitted were divided into study group(n=35)and control group(n=35).Both groups received standardized behavioral intervention courses.The study group simultaneously implemented rTPJ-targeted LF-rTMS,and control group implemented rTPJ-targeted sham stimulation.The behavioral changes were assessed with the child autism rating scale(CARS),autism behav-ior scale(ABC),and repetitive behavior scale revised(RBS-R)at baseline and 8 weeks after treatment,respective-ly,and resting EEG data were collected simultaneously to quantify the characteristics of neural oscillations by theta band(4-7Hz)PSD values.Results:After 8 weeks of intervention,the total scores of CARS,ABC,and RBS-R in both groups decreased compared to those before treatment(P＜0.01).There was no statistically significant differ-ence in the total scores of CARS and ABC between the study group and the control group,but the total RBS-R score in the study group was lower than that in the control group(P＜0.05).After 8 weeks of intervention,the PSD val-ues at the P4(right parietal region)and C4(right central region)sites in the θ frequency band decreased in the study group compared to those before treatment(P＜0.01).However,there was no statistically significant difference in the PSD values of θ waves at any site between the study group and the control group.Conclusion:The rTPJ-targeted LF-rTMS intervention on the basis of conventional rehabilitation did not significantly improve ASD core social defi-cits,but it could effectively alleviate repetitive stereo-typed behavior,which may be related to the regulation of theta band overactivation in right hemisphere senso-rimotor integration cortex(C4/P4).关键词
低频重复经颅磁刺激/孤独症/右侧颞顶交界区/静息态脑电图/功率谱密度Key words
low-frequency repetitive transcranial magnetic stimulation/autism/right temporoparietal junction/resting electroencephalogram/power spectral density分类
临床医学引用本文复制引用
王敏,王秋爽,仇爱珍,鲍克秀,郑会敏..右颞顶交界区低频经颅磁刺激对孤独症儿童刻板行为的影响[J].中国康复,2025,40(11):660-664,5.基金项目
徐州市重点研发计划(社会发展)项目-医药卫生面上项目(KC22197) （社会发展）
