中国康复理论与实践2025，Vol.31Issue(11)：1256-1264,9.DOI:10.3969/j.issn.1006-9771.2025.11.002
缺血性脑卒中手功能障碍患者静息态脑功能的活动特征
Characteritics of resting state brain functional activities in patients with hand dysfunction after ischemic stroke
摘要
Abstract
Objective To explore the characteritics of spontaneous brain functional activities for patients with hand dysfunction after ischemic stroke using resting state functional magnetic resonance imaging(rs-fMRI). Methods From August,2024 to June,2025,23 patients with hand dysfunction after ischemic stroke were as patients group,and ten age-matched healthy adults were recruited as healthy control group.The patients group was as-sessed with Fugl-Meyer Assessment-Upper Extremities(FMA-UE),Wolf Motor Function Test(WMFT)and modified Lindmark Scale.All subjects underwent rs-fMRI examinations,and the amplitude of low frequency fluctuations(ALFF),fractional amplitude of low frequency fluctuations(fALFF)and regional homogeneity(Re-Ho)were compared between two groups.The resting state functional network was constructed based on indepen-dent component analysis,and the functional connectivity(FC)were analyzed.The rs-fMRI indicators of the pa-tients and the clinical scale scores were analyzed. Results Compared with the healthy control group,the zALFF value decreased in the precentral gyrus(P<0.05,FWE corrected)in the patient group,as well as the values of zfALFF in Cerebelum-Crus2-R(P<0.05,FWE correct-ed),and ReHo values in the putamen(P<0.05,corrected by Alpha Sim).FC of the inferior frontal gyrus(IF-Goperc.R)in the executive control network enhanced(P<0.05,Alpha Sim corrected),while FC of the middle oc-cipital gyrus(MOG.L)in the dorsal attention network(DAN)weakened(P<0.05,Alpha Sim corrected).There was a positive correlation between FC of MOG.L in the patient's DAN and the scores of FMA-UE(r=0.439,P=0.036),WMFT(r=0.516,P=0.012),and modified Lindmark Scales(r=0.425,P=0.043). Conclusion The resting state spontaneous activity of some brain areas of the cerebrum,cerebellum and basal ganglia is reduced in patients with hand dysfunction after ischemic stroke,and some brain network connections are abnor-mal.FC of MOG.L may serve as an objective imaging marker for evaluating hand dysfunction.关键词
缺血性脑卒中/手功能/静息态功能性磁共振Key words
ischemic stroke/hand function/resting state functional magnetic resonance imaging分类
医药卫生引用本文复制引用
王辉煌,李雪静,刘福,陈思航,李疏影,蒲昱帆..缺血性脑卒中手功能障碍患者静息态脑功能的活动特征[J].中国康复理论与实践,2025,31(11):1256-1264,9.基金项目
国家自然科学基金项目(No.82105004) Supported by National Natural Science Foundation of China(No.82105004) （No.82105004）
