中国康复理论与实践2025，Vol.31Issue(11)：1290-1302,13.DOI:10.3969/j.issn.1006-9771.2025.11.006
不同虚拟现实技术对帕金森病患者运动功能疗效的网状Meta分析
Comparison of different virtual reality technologies on motor function in Parkinson's disease:a network meta-analysis
摘要
Abstract
Objective To systematically compare the efficacy of different virtual reality(VR)technologies on motor dysfunction in patients with Parkinson's disease(PD)through a network meta-analysis(NMA). Methods Following the PRISMA-NMA guidelines,randomized controlled trials(RCT)that compared the effect of at least two interventions on motor function in patients with PD were searched in PubMed,Embase,Cochrane Li-brary,Web of Science,CNKI,Wanfang data and VIP.The interventions included immersive virtual reality(IVR),non-immersive virtual reality(VRT),augmented reality(AR),treatment as usual(TAU)and active control(AC).The primary outcomes included Unified Parkinson's Disease Rating Scale Part Ⅲ(UPDRS-Ⅲ),Berg Balance Scale(BBS)and Timed Up and Go Test(TUGT).A frequentist-based random-effects model was used to conduct NMA,and the surface under the cumulative ranking curve(SUCRA)was used to rank the interventions. Results A total of 20 RCT involving 890 patients were included.IVR performed best in improving the score of UPDRS-Ⅲ(SUCRA=97.7%)and was significantly superior to TAU(SMD=-0.82,95%CI-1.28 to-0.37).IVR showed the highest probability of being the best option for the score of BBS(SUCRA=85.2%)and was signifi-cantly superior to TAU(SMD=3.94,95%CI 1.08 to 6.80).IVR performed best in the outcome of TUGT(SU-CRA=95.1%)and was significantly superior to VRT(SMD=1.06,95%CI 0.40 to 1.72),AR(SMD=-1.09,95%CI-1.98 to-0.19)and TAU(SMD=-1.38,95%CI-1.95 to-0.82).However,subgroup analysis revealed that the efficacy advantage of IVR was mainly confirmed in short-term(four to six weeks)interventions,while the evidence for long-term efficacy was currently very limited. Conclusion The efficacy of interventions on motor rehabilitation in patients with PD appears to be positively correlated with the technology's level of immersion.As the most immersive technology,IVR is the optimal choice for im-proving overall motor function,balance and mobility in patients with PD.VRT and AR serve as effective adju-vants and are superior to TAU.关键词
帕金森病/虚拟现实/运动功能/网状Meta分析Key words
Parkinson's disease/virtual reality/motor activity/network meta-analysis分类
医药卫生引用本文复制引用
张浩,许传蕾,魏振兴,马丽虹..不同虚拟现实技术对帕金森病患者运动功能疗效的网状Meta分析[J].中国康复理论与实践,2025,31(11):1290-1302,13.基金项目
山东省高等医学教育研究中心科研规划项目(No.YJKT202112) Supported by Shandong Higher Medical Education Research Center Project(No.YJKT202112) （No.YJKT202112）
