中国临床药理学杂志2025，Vol.41Issue(17)：2429-2434,6.DOI:10.13699/j.cnki.1001-6821.2025.17.006
咪达唑仑联合丙泊酚在重度肥胖患者胃切除术中的临床研究
Clinical trial of midazolam combined with propofol in severely obese patients undergoing gastrectomy
摘要
Abstract
Objective To investigate the clinical efficacy and safety of midazolam injection combined with propofol medium/long-chain fat emulsion target-controlled infusion(TCI)in severely obese patients undergoing laparoscopic sleeve gastrectomy with double-tract anastomosis(LSG-DJB).Methods Severely obese patients treated in our hospital were randomly assigned by a random number table method to the control group or the treatment group.The control group received propofol medium/long-chain fat emulsion TCI(effect-site concentration 1.2-2.0 μg·mL-1),while the treatment group additionally received midazolam injection(0.03 mg·kg-1 for induction,0.02 mg·kg-1·h-1 for maintenance).Pain indicators,recovery quality,inflammatory markers,oxidative stress parameters and safety outcomes were compared between the two groups.Results A total of 179 patients were screened in this study,with 67 cases enrolled in the control group and 68 cases in the treatment group.Three cases dropped out in the control group and four cases dropped out in the treatment group;ultimately,64 cases in each group completed the study.The pain scores(NRS)at discharge from the operating room were(0.76±0.42)and(0.93±0.28)points for the treatment group and control group,respectively;at 6 hours postoperatively,they were(1.94±0.46)and(2.37±0.82)points,respectively;at 12 hours postoperatively,they were(2.24±0.51)and(2.92±0.71)points,respectively.Compared with the control group,the differences in the above indicators in the treatment group were statistically significant(all P＜0.05).The total intraoperative dosage of sufentanil injection were(0.75±0.12)and(0.92±0.15)μg·kg-1 for the treatment group and control group,respectively;the eye-opening time was(10.77±1.48)and(8.39±1.23)min,respectively;the extubation time was(18.68±2.91)and(13.21±2.48)min,respectively;the respiratory recovery time was(16.87±2.25)and(11.93±2.03)min,respectively.Compared with the control group,the differences in the above indicators in the treatment group were statistically significant(all P＜0.05).At 24 hours postoperatively,the serum interleukin-6(IL-6)levels were(72.16±10.28)and(88.32±11.14)ng·L-1 for the treatment group and control group,respectively;tumor necrosis factor-α(TNF-α)levels were(152.47±21.95)and(176.84±25.67)ng·L-1,respectively;C-reactive protein(CRP)levels were(5.63±0.88)and(7.74±0.86)mg·L-1,respectively;malondialdehyde(MDA)levels were(4.82±1.19)and(7.03±1.22)mmol·mL-1,respectively;cortisol(Cor)levels were(31.42±3.27)and(37.75±4.16)μg·dL-1,respectively;superoxide dismutase(SOD)levels were(37.38±5.82)and(23.67±3.59)mmol·mL-1,respectively.Compared with the control group,the differences in the above indicators in the treatment group were statistically significant(all P＜0.05).The main adverse drug reactions in the treatment group were hypoxemia,hypotension,delayed recovery,nausea and vomiting;the main adverse reactions in the control group were nausea and vomiting,hypoxemia,and hypotension.The total incidence rates of adverse drug reactions were 54.69％and 42.19％in the treatment group and control group,respectively,with no statistically significant difference(P＞0.05).Conclusion Midazolam injection combined with propofol medium/long-chain fat emulsion TCI provides optimized sedation depth,reduces inflammatory and stress responses,and demonstrates good safety in severely obese patients undergoing LSG-DJB.关键词
咪达唑仑注射液/丙泊酚中/长链脂肪乳注射液/重度肥胖/腹腔镜袖状胃切除/双通路吻合术/靶控输注Key words
midazolam injection/propofol medium/long-chain fat emulsion injection/severe obesity/laparoscopic sleeve gastrectomy/double-tract anastomosis/target-controlled infusion分类
临床医学引用本文复制引用
马擎,李莉,朱珊珊,王巧妍,陈浩..咪达唑仑联合丙泊酚在重度肥胖患者胃切除术中的临床研究[J].中国临床药理学杂志,2025,41(17):2429-2434,6.基金项目
江苏省重点研发计划基金资助项目(BE2022049) （BE2022049）
