中国临床药理学杂志2025，Vol.41Issue(18)：2551-2566,16.DOI:10.13699/j.cnki.1001-6821.2025.18.001
中国细菌耐药监测研究(CARST)2023-2024年革兰氏阳性菌监测报告
Antimicrobial susceptibility of gram-positive organisms:Results from China antimicrobial resistance surveillance trial(CARST)program,2023-2024
李耘 1俞云松 2蔡璇 3刘文恩 4刘德华 5费樱 6刘家云 7裴凤艳 8孟灵 9季萍 10汤进 11郑波 1朱镭 12潘开素 13徐和平 14张健东 15薛峰 1王珊 1刘姚姚 1钟巍 1崔兰卿 1张秀珍 16胡云建 16金玉芬 17潘世扬 18郭玮 19赵锋20
作者信息
- 1. 北京大学第一医院临床药理研究所,北京 100034
- 2. 浙江大学医学院附属邵逸夫医院感染科,浙江 杭州 310003
- 3. 武汉大学人民医院检验科,湖北武汉 430060
- 4. 中南大学湘雅医院检验科,湖南长沙 410008
- 5. 昆明市第一人民医院检验科,云南 昆明 650011
- 6. 贵州医科大学附属医院检验科,贵州贵阳 550001
- 7. 空军军医大学西京医院检验科,陕西西安 710032
- 8. 济南市中心医院检验科,山东济南 250013
- 9. 兰州大学第二医院检验科,甘肃兰州 730030
- 10. 新疆医科大学第一医院检验科,新疆维吾尔自治区乌鲁木齐 830054
- 11. 汉中市中心医院检验科,陕西汉中 723000
- 12. 山西省儿童医院检验科,山西太原 300012
- 13. 广西医科大学第一附属医院皮肤科,广西壮族自治区南宁 530021
- 14. 厦门大学附属第一医院检验科,福建厦门 361003
- 15. 天津市第三中心医院检验科,天津 300170
- 16. 北京医院检验科,北京 100730
- 17. 吉林大学第二医院检验科,吉林长春 130041
- 18. 南京医科大学第一附属医院检验科,江苏南京 210029
- 19. 复旦大学中山医院检验科,上海 200023
- 20. 浙江大学医学院附属邵逸夫医院检验科,浙江 杭州 310003
- 折叠
摘要
Abstract
Objective To investigate the gram-positive coccus resistance in nationwide tietiary hospitals,understand the trend of antimicrobial resistance and provide scientific data for the rational use of antibiotis.Method All the clinical isolates were collected from 18 hospitals and the minimal inhibitory concentrations(MICs)were tested using agar/broth dilution method recommended by Clinical and Laboratory Standards Institute(CLSI)in central laboratory.Results A total of 2 311 pathogenic gram-positive coccus from 18 tertiary hospitals in 18 cities nationwide over the period from July 2023 to June 2024 were studied.Based on the MIC results,the prevalence of methicillin resistant Stapylococcus aureus(MRSA)and methicillin resistant Stapylococcus epidermidis(MRSE)were 30.6％and 76.3％,respectively.No vancomycin insensitivitive Staphylococcus was detected.Stapylococcus aureus were 100％susceptible to linezolid and teicoplanin.Antibiotic resistance rates of Enterococcus faecalis and Enterococcus faecium to ampicillin were 0.6％and 89.1％,respectively.18 strains of vancomycin-resistant Enterococcus(VRE)were detected,all of which was Enterococcus faecium.The detection rate of VRE among Enterococcus faecium was 5.5％.The prevalence of penicillin non-susceptible Streptococcus pneumoniae(PNSSP)was 9.9％based on non-meningitis and parenteral administration criterion,while for cases of oral penicillin,the rate was 73.1％,showing similar to last time.The resistance rates of Streptococcus pneumoniae from children to cephalosporins,macrolides and clindamycin were slightly higher than those of adults and the elderly,while there were no statistic significant differences of resistance rates of Stapylococcus aureus,Stapylococcus epidermidis,Enterococcus faecalis,Enterococcus faecium and Streptococcus pneumoniae among various groups such as different departments,ages,or specimen sources(all P＞0.05).Conclusion The detection rate of MRSA has continued to decline,while the detection rate of VRE has been on the rise.This situation requires continuous monitoring.关键词
细菌耐药监测/革兰氏阳性菌/最低抑菌浓度/敏感率/耐药率/最低抑菌浓度分布Key words
antimicrobial resistance surveillance/gram-positive cocci/minimum inhibitory concentration/susceptibility/resistance/minimal inhibitory concentration distribution分类
医药卫生引用本文复制引用
李耘,俞云松,蔡璇,刘文恩,刘德华,费樱,刘家云,裴凤艳,孟灵,季萍,汤进,郑波,朱镭,潘开素,徐和平,张健东,薛峰,王珊,刘姚姚,钟巍,崔兰卿,张秀珍,胡云建,金玉芬,潘世扬,郭玮,赵锋..中国细菌耐药监测研究(CARST)2023-2024年革兰氏阳性菌监测报告[J].中国临床药理学杂志,2025,41(18):2551-2566,16.
