中国临床药理学杂志2025，Vol.41Issue(18)：2685-2691,7.DOI:10.13699/j.cnki.1001-6821.2025.18.020
线粒体自噬在骨性关节炎中的调控机制及中医药干预研究进展
Research status of regulatory mechanism of mitochondrial autophagy in osteoarthritis and intervention of traditional Chinese medicine
摘要
Abstract
Osteoarthritis,a degenerative bone disease commonly seen in the elderly,is particularly prevalent in weight-bearing joints such as the knee.Its etiology is multifactorial and characterized by pathological changes in the joint structure,including destruction and degeneration of articular cartilage,inflammatory response and formation of bone capillaries.Up to now,clinical treatment for osteoarthritis is mainly symptomatic treatment and pain relief,and there is no exact therapy that can reverse the pathological process of cartilage damage in osteoarthritis.In recent years,domestic and foreign scholars have found that mitochondria,as important organelles of chondrocytes,plays an important role in the process of cell metabolism,proliferation and apoptosis.It is also pointed out that mitochondrial autophagy imbalance is an important factor leading to cartilage damage in joints.Meanwhile,several basic experiments have shown that Chinese medicine exhibits the potential to protect cartilage by targeting the regulation of mitochondrial autophagy,thus showing positive results in the prevention and treatment of osteoarthritis.However,studies on this area have not been systematically elaborated.In view of this,the authors will systematically elaborate on the effects of mitochondrial autophagy on the development of osteoarthritis and the role of TCM in interfering with mitochondrial autophagy in the treatment of osteoarthritis,with the aim of providing new ideas and methods for the development of new medicines and therapeutic strategies for the treatment of osteoarthritis with TCM.关键词
中医药/骨性关节炎/软骨损伤/线粒体自噬Key words
traditional Chinese medicine/osteoarthritis/cartilage damage/mitochondrial autophagy分类
中医学引用本文复制引用
张循儒,李红专,王飞,陈宗阳,梁家齐,温力鹏,李中锋..线粒体自噬在骨性关节炎中的调控机制及中医药干预研究进展[J].中国临床药理学杂志,2025,41(18):2685-2691,7.基金项目
甘肃省临床医学研究中心建设基金资助项目(18JR2FA009) （18JR2FA009）
甘肃省科技计划基金资助项目(21YF5FA025) （21YF5FA025）
甘肃省中医药科研基金资助项目(GZKP-2023-4) （GZKP-2023-4）
