中国免疫学杂志2025，Vol.41Issue(11)：2713-2719,7.DOI:10.3969/j.issn.1000-484X.2025.11.026
ICU脓毒症患者早期液体平衡与调节性T细胞表型变化的关系及对预后的影响
Relationship between early fluid balance and phenotypic changes of regulatory T cells in patients with sepsis in ICU and its influence on prognosis
路晔 1张辰岑2
作者信息
- 1. 无锡市第五人民医院重症医学科,无锡 214001
- 2. 无锡市中医医院肿瘤科,无锡 214001
- 折叠
摘要
Abstract
Objective:To explore relationship between early fluid balance and phenotypic changes of Treg in patients with sep-sis in ICU and its influence on prognosis.Methods:Ninety-eight patients with sepsis admitted to Wuxi Fifth People's Hospital from June 2018 to June 2023 were selected as study objects,and divided into death group(n=34)and survival group(n=64)according to whether patients died within 28 days after admission to ICU.Clinical data,fluid balance,CD4+CD25+Foxp3+Treg and CD4+CD25+Treg levels after 24 h and 72 h in ICU were compared between two groups.Multivariate Logistic regression was used to analyze correlation between fluid balance and CD4+CD25+Foxp3+Treg and CD4+CD25+Treg.Influencing factors of death in patients with sepsis in ICU were screened and corresponding prediction model was established.Results:Age,sequential organ failure assessment(SOFA)score,acute physiology and chronic health evaluation(APACHE Ⅱ)score,fluid balance 24 h and 72 h after ICU admission,CD4+CD25+Foxp3+Treg and CD4+CD25+Treg levels were significantly higher than survival group(P<0.05).Multivariate Logistic regres-sion analysis showed that age,SOFA score,APACHE Ⅱ score,fluid balance at 24 h and 72 h after ICU admission,CD4+CD25+Foxp3+Treg and CD4+CD25+Treg levels at 24 h after ICU admission were all risk factors for death at 28 days after ICU admission(P<0.05).Combined with the above five factors to build a predictive model with high sensitivity and accuracy.Conclusion:Higher fluid balance and CD4+CD25+Foxp3+Treg and CD4+CD25+Treg levels are risk factors for death in patients with sepsis in ICU,and they are significantly positively correlated.关键词
脓毒症/液体平衡/Treg/相关性/预后Key words
Sepsis/Fluid balance/Treg/Relevance/Prognosis分类
临床医学引用本文复制引用
路晔,张辰岑..ICU脓毒症患者早期液体平衡与调节性T细胞表型变化的关系及对预后的影响[J].中国免疫学杂志,2025,41(11):2713-2719,7.
