中国免疫学杂志2025，Vol.41Issue(11)：2756-2763,8.DOI:10.3969/j.issn.1000-484X.2025.11.034
神经炎症疾病中星形胶质细胞和小胶质细胞互作机制的研究进展
Advances in mechanism of astrocyte-microglia crosstalk in neuroinflammatory diseases
摘要
Abstract
Neuroinflammation refers to the innate and adaptive immune responses initiated by various immune cells releasing inflammatory mediators after harmful injury.Neuroinflammatory diseases are diseases caused by inflammatory reactions in the nervous system.Astrocytes are the most common glial cell type in central nervous system.Microglia,as immune cells,have ability to monitor and clear pathological damage.Recent studies have shown that there are complex interactions between astrocytes and microglia,which together participate in the progression of neuroinflammatory diseases and play a key regulatory role.This review briefly introduces the interaction mechanisms between astrocytes and microglia in neuroinflammatory diseases,including Alzheimer's disease,Parkinson's disease,multiple sclerosis,amyotrophic lateral sclerosis,Huntington's disease and migraine,aims to provide new ideas and methods for the treatment of neuroinflammatory diseases.关键词
神经炎症/小胶质细胞/星形胶质细胞/互相作用/研究进展Key words
Neuroinflammation/Microglia/Astrocyte/Interaction/Research progress分类
基础医学引用本文复制引用
张程程,张欣雨,刘璐..神经炎症疾病中星形胶质细胞和小胶质细胞互作机制的研究进展[J].中国免疫学杂志,2025,41(11):2756-2763,8.基金项目
国家自然科学基金项目(82074179,82374575) （82074179,82374575）
北京市自然科学基金项目(7232270) （7232270）
首都优秀青年人才B类项目(B2207). （B2207）
