中国脑血管病杂志2025，Vol.22Issue(11)：777-784,8.DOI:10.3969/j.issn.1672-5921.2025.11.006
脑增生性血管病变研究进展
Research advances in cerebral proliferative angiopathy
摘要
Abstract
Cerebral proliferative angiopathy(CPA)was initially regarded as a variant of arteriovenous malformation.However,its distinct histological,angiographic,and pathophysiological features have led to its reclassification as an independent entity.CPA is an exceptionally rare form of cerebral vascular malformation,its pathogenesis is primarily linked to diffuse vascular proliferation secondary to chronic hypoperfusion.Clinically,CPA presents with a heterogeneous spectrum of manifestations,most commonly severe headaches and epileptic seizures.Neuroimaging(MR)typically reveals a complex interplay of aberrant vessels within the brain parenchyma,which may complicate the clinical management and lead to a higher rate of poor prognosis.This article reviewed current knowledge on the pathogenesis,epidemiology,clinical features,diagnostic approaches,and treatment options for CPA,with the aim of enhancing understanding of its underlying mechanisms and guiding future therapeutic strategy optimizations.关键词
脑增生性血管病变/临床表现/发病机制/综述Key words
Cerebral proliferative angiopathy/Clinical manifestations/Pathogenesis/Review引用本文复制引用
李毅,马永杰,秦驁,张鸿祺,苏新..脑增生性血管病变研究进展[J].中国脑血管病杂志,2025,22(11):777-784,8.基金项目
国家自然科学基金(82220108010) （82220108010）
