中国比较医学杂志2025，Vol.35Issue(10)：88-100,13.DOI:10.3969/j.issn.1671-7856.2025.10.010
星形胶质细胞-神经元能量代谢偶联失衡在AD发生发展中的作用及中药干预研究进展
Role of astrocyte-neuron energy metabolism coupling imbalance in the pathogenesis and progression of Alzheimer's disease and research progress in traditional Chinese medicine interventions
摘要
Abstract
Energy metabolism disorders are a critical factor contributing to cognitive dysfunction.Astrocytes,as key suppliers of energy substrates to neurons,help to sustain normal cognitive function via their extensive energy metabolism activities in the brain,coordinated by various energy supply mechanisms.Imbalances in astrocyte-neuron energy metabolism coupling lead to abnormal neuronal activity,thereby driving the pathogenesis and progression of Alzheimer's disease(AD).It is therefore essential to investigate the pathological mechanisms and therapeutic targets associated with AD from the perspective of energy metabolism to support the future development of AD treatments and interventions.Traditional Chinese medicine(TCM),characterized by multi-component and multi-target effects,has shown potential efficacy for regulating cerebral energy metabolism,suggesting that modulating brain energy metabolism may represent a significant pathway by which TCM might ameliorate AD.This review systematically elucidates the mechanistic role of the dysregulation of astrocyte-neuron bioenergetic coupling in the pathogenesis and progression of AD,and critically evaluates recent advancements in therapeutic interventions mediated by TCM.关键词
星形胶质细胞/神经元/能量代谢/阿尔茨海默病/中药Key words
astrocytes/neurons/energy metabolism/Alzheimer's disease/traditional Chinese medicine分类
医药卫生引用本文复制引用
杨雨欣,邵世泰,王文攀,王潘,谢治深,孙意冉,张振强,马慧芬..星形胶质细胞-神经元能量代谢偶联失衡在AD发生发展中的作用及中药干预研究进展[J].中国比较医学杂志,2025,35(10):88-100,13.基金项目
国家自然科学基金(82305087,82274612) （82305087,82274612）
河南省科技攻关(242102311258) （242102311258）
河南省重点研发专项(231111312900) （231111312900）
河南省高校科技创新人才(25HASTIT062) （25HASTIT062）
中国博士后面上项目(2022M711080) （2022M711080）
河南省高校重点科研项目(23A310013). （23A310013）
