中国比较医学杂志2025，Vol.35Issue(10)：149-161,13.DOI:10.3969/j.issn.1671-7856.2025.10.015
溶瘤病毒在肿瘤免疫原性细胞死亡中的研究进展
Research progress in the use of oncolytic viruses to induce tumor immunogenic cell death
张思博 1贾丽芳 1李璐璐 2王静 3刘开扬1
作者信息
- 1. 河北北方学院生命科学研究中心,河北 张家口 075000
- 2. 河北北方学院中医学院,河北 张家口 075000
- 3. 河北北方学院生命科学研究中心,河北 张家口 075000||河北北方学院微循环研究所,河北 张家口 075000
- 折叠
摘要
Abstract
Immunogenic cell death(ICD)is a form of cell death that can activate the immune system,especially in the treatment of cancer.ICD can enhance the recognition of tumors by the immune system and the release of damage associated molecular patterns(DAMPs),to achieve tumor cell death.Oncolytic viruses(OVs)can selectively infect and kill tumor cells without damaging normal cells.OVs are type Ⅱ ICD inducers that induce ICD in tumor cells by targeting the endoplasmic reticulum.Here,we review the characteristics of ICD and the mechanism of ICD induction by OVs.We also review the latest clinical progress involving ICD and discuss future treatment strategies for tumors.关键词
溶瘤病毒/免疫原性细胞死亡/损伤相关分子模式/研究进展Key words
oncolytic virus/immunogenic cell death/damage-associated molecular patterns/research progress分类
临床医学引用本文复制引用
张思博,贾丽芳,李璐璐,王静,刘开扬..溶瘤病毒在肿瘤免疫原性细胞死亡中的研究进展[J].中国比较医学杂志,2025,35(10):149-161,13.
