中国实用内科杂志2025，Vol.45Issue(10)：823-826,837,5.DOI:10.19538/j.nk2025100104
阿尔茨海默病认知连续谱及其转化与病理标志物研究进展
Research progress on cognitive continuum spectrum,its transformation and pathological markers of Alzheimer's disease
摘要
Abstract
Alzheimer's disease(AD)is a progressive neurodegenerative disorder characterized by β-amyloid deposition,hyperphosphorylated tau pathology,and neuronal loss,which could begin 10-20 years before onset of clinical symptoms.Advances in biomarker research and the concept of the cognitive continuum have shifted the diagnosis of AD from a clinically based framework to a biology-centered approach.Blood-based and neuroimaging biomarkers now enable early screening and diagnosis,and predict disease progression and prognosis.Furthermore,the trajectory of AD cognitive continuum is influenced by genetic factors,comorbidities,lifestyle,and cognitive reserve.Multimodal interventions,anti-amyloid immunotherapies,digital tools,and neuromodulation devices offer promising strategies for early interventions,contributing to delayed disease progression and improved outcomes.关键词
阿尔茨海默病/认知连续谱/疾病转化/多模式干预Key words
Alzheimer's disease/cognitive continuum/disease transition/multimodal intervention分类
临床医学引用本文复制引用
毛铭,田民乐,李雪玮,陈紫薇,韩晓娟..阿尔茨海默病认知连续谱及其转化与病理标志物研究进展[J].中国实用内科杂志,2025,45(10):823-826,837,5.基金项目
山东省自然科学基金面上项目(ZR2023MH310) （ZR2023MH310）
山东省重点研发计划(2018GSF121009) （2018GSF121009）
山东省自然科学基金博士基金(ZR2019BH074) （ZR2019BH074）
