中国实用内科杂志2025，Vol.45Issue(10)：858-863,6.DOI:10.19538/j.nk2025100111
共病的流行病学特征及其与痴呆症的关系
Epidemiological characteristics of multimorbidity and its relationship with dementia
摘要
Abstract
Multimorbidity refers to the coexistence of two or more chronic diseases within a single individual and can be classified based on disease cluster patterns.Differences in demographic,socioeconomic,and lifestyle factors are major risk contributors to multimorbidity.Importantly,multimorbidity substantially increases the risk of dementia.Certain multimorbidity patterns,such as cardiometabolic multimorbidity(CMM),as well as earlier age at onset,are strongly associated with higher dementia risk.Neuroimaging studies have demonstrated that multimorbidity is linked to neurodegenerative and cerebrovascular imaging markers,including reduced brain volume,enlarged ventricles,and cerebrovascular lesions.Moreover,multimorbidity is significantly associated with Alzheimer's disease(AD)fluid biomarkers,such as a decreased Aβ42/Aβ40 ratio and elevated P-tau/Aβ42 and T-tau/Aβ42 ratios.Standardization of defining multimorbidity patterns,future prospective longitudinal cohort studies,and randomized controlled trials,and further explorations of mechanisms linking multimorbidity with dementia will facilitate earlier interventions to delay or prevent dementia and promote a paradigm shift from single-disease management to integrated strategies targeting multiple health risks.关键词
共病/心脏代谢性共病/痴呆/影像标志物/体液标志物Key words
multimorbidity/cardiometabolic multimorbidity/dementia/image marker/body fluid marker分类
临床医学引用本文复制引用
刘翠翠,任奕霏,丁雪然,李嘉慧,王婷婷,李金坪,丛琳..共病的流行病学特征及其与痴呆症的关系[J].中国实用内科杂志,2025,45(10):858-863,6.基金项目
科技创新2030-脑科学与类脑研究重大项目(2022ZD0211600) （2022ZD0211600）
