中国兽医杂志2025，Vol.61Issue(11)：9-16,8.DOI:10.20157/j.cnki.zgsyzz.2025.11.002
2023-2024年鄱阳湖地区都昌县活禽市场低致病性禽流感病毒监测和分析
Surveillance and Analysis of Low Pathogenic Avian Influenza Viruses in Live Poultry Markets of Duchang County,Poyang Lake Region,2023-2024
摘要
Abstract
To investigate the prevalence of low pathogenic avian influenza virus(LPAIV)in live poultry markets(LPMs)in the Poyang Lake region of Jiangxi Province and to assess its public health risk,this study conducted continuous surveillance in the LPMs of Duchang County from June 2023 to May 2024.A total of 811 samples were collected from chickens,ducks,and environmental sources.Virus isolation was performed in chicken embryos,and pathogen detection was carried out to analyze the prevalence of LPAIV,the distribution of subtypes across different months,the source-specific distribution of LPAIV isolates,and the receptor-binding characteristics of different subtypes.The overall detection rate of LPAIV was 53.4%(433/811),with the H9 subtype being the most prevalent(27.5%,223/811),followed by H6(9.4%,76/811)and H3(1.6%,13/811).Mixed infections involving multiple LPAIV subtypes were commonly observed,and H6 and H9 subtype LPAIV were detected every month.Environmental samples had the highest LPAIV detection rate(68.9%),followed by chicken-derived samples(60.2%)and duck-derived samples(41.7%).H9 was the dominant subtype in chickens,whereas duck and environmental samples showed greater subtype diversity,mainly H3 and H6,along with mixed infections.Receptor-binding analysis revealed that H9 isolates showed stronger affinity for α-2,6 sialic acid receptors,indicating potential for cross-species transmission,while H3 and H6 isolates preferentially bound to α-2,3 sialic acid receptors.This study demonstrates that H3,H6,and H9 subtypes of LPAIV are persistently circulating in Duchang County's live poultry markets,with frequent mixed infections.The H9 subtype,in particular,poses a potential risk for interspecies transmission.Strengthened surveillance and environmental sanitation in LPMs are recommended.The findings provide valuable reference data for avian influenza prevention strategies in the Poyang Lake region and enrich the national epidemiological database on avian influenza in live poultry markets.关键词
低致病性禽流感病毒(LPAIV)/活禽市场/鄱阳湖/流行病学/受体结合特性Key words
low pathogenic avian influenza viruse(LPAIV)/live poultry market/Poyang Lake/epidemiology/receptor-binding characteristic分类
畜牧业引用本文复制引用
束思成,姚富晓,曹志勇,孙剑锋,曹起,佟琪,孙洪磊,蒲娟..2023-2024年鄱阳湖地区都昌县活禽市场低致病性禽流感病毒监测和分析[J].中国兽医杂志,2025,61(11):9-16,8.基金项目
国家重点研发计划(2022YFF0802400) （2022YFF0802400）
