中国心理卫生杂志2025，Vol.39Issue(12)：1037-1042,6.DOI:10.3969/j.issn.1000-6729.2025.12.05
产前环境因素与儿童注意缺陷多动障碍的关联研究
Associations between prenatal environmental factors on attention deficit hyperactivity disorder in children
摘要
Abstract
Objective:To investigate the association between prenatal environmental factors and attention defi-cit hyperactivity disorder(ADHD)and its symptom severity in children.Methods:Based on the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition(DSM-Ⅳ)diagnosis criteria,1 156 children with ADHD and 289 normal control children were included in this study.ADHD diagnoses were established using the Clinical Diag-nostic Interview Scale,core symptoms were assessed with the ADHD Rating Scale,and information on prenatal ex-posures were collected via self-developed questionnaires.Results:Maternal stress during pregnancy was associated with increased risk factor of ADHD in children(OR=1.22,P＜0.01).Among children with ADHD,preconception paternal alcohol consumption was positively associated with hyperactivity/impulsivity symptoms(β=0.08,P＜0.05),and maternal smoking during pregnancy was positively associated with total symptoms(β=0.07-0.09,P＜0.05).Conclusion:Maternal stress during pregnancy may increase the risk factor of ADHD in children.Both pre-conception paternal alcohol consumption and maternal smoking during pregnancy may be associated with increased ADHD symptom severity in children.关键词
注意缺陷多动障碍/危险因素/产前应激/产前吸烟/受孕时父亲饮酒Key words
attention deficit hyperactivity disorder(ADHD)/risk factors/maternal stress during pregnan-cy/maternal smoking during pregnancy/preconception paternal alcohol consumption分类
临床医学引用本文复制引用
杨子琦,岳鑫鑫,刘璐,钱秋谨,王玉凤..产前环境因素与儿童注意缺陷多动障碍的关联研究[J].中国心理卫生杂志,2025,39(12):1037-1042,6.基金项目
北京市科技新星计划(20220484061),国家自然科学基金(82271575),北京大学临床医学+X青年专项,中央高校基本科研业务费(PKU2023LCXQ043) （20220484061）
