中国药房2025，Vol.36Issue(22)：2778-2782,5.DOI:10.6039/j.issn.1001-0408.2025.22.05
当归-茯苓药对干预过敏性鼻炎的作用机制预测及验证
Prediction and verification of the mechanism of action of herb pair of Angelica sinensis-Poria cocos in intervening in allergic rhinitis
摘要
Abstract
OBJECTIVE To study the mechanism of action of herb pair of Angelica sinensis-Poria cocos in intervening in allergic rhinitis.METHODS The core targets of herb pair of A.sinensis-P.cocos in intervening in allergic rhinitis were predicted through network pharmacology.Allergic rhinitis model of rats was established by intraperitoneal injection of aluminum hydroxide and ovalbumin mixture,and the rats were randomly divided into model group,loratadine group(positive control group,0.9 mg/kg),and low-,medium-,high-dose groups of herb pair of A.sinensis-P.cocos(3,6 and 12 g/kg),with 10 rats in each group.Another 10 healthy rats were used as the normal group.Each group of rats was intragastrically administered the corresponding liquid or normal saline once a day for 30 consecutive days.After the last administration,the behavioral scores of each group of rats were calculated,the levels of immunoglobulin E(IgE),histamine,interleukin-4(IL-4)in serum,and the protein expression levels of IL-6,tumor necrosis factor-α(TNF-α),and prostaglandin-endoperoxide synthase 2(PTGS2)in nasal mucosa tissue were detected.The pathological morphology changes of nasal mucosa tissue were observed.RESULTS Network pharmacology analysis revealed that IL-6,TNF and PTGS2 might play a key role in the intervention of allergic rhinitis by herb pair of A.sinensis-P.cocos,and the IL-17 and TNF signaling pathways might be the typical inflammatory signaling pathways intervened by herb pair of A.sinensis-P.cocos in allergic rhinitis.The results of animal experiments showed that compared with the model group,the behavioral score,the levels of IgE,histamine and IL-4,and the protein expressions of IL-6,TNF-α and PTGS2 in each administration group were decreased significantly(P＜0.05),and there was a dose-dependent relationship with the herb pair of A.sinensis-P.cocos(P＜0.05).CONCLUSIONS The herb pair of A.sinensis-P.cocos can effectively alleviate the symptoms of rats with allergic rhinitis,the mechanism of which may be related to the inhibition of the expressions of IL-6,TNF-α and PTGS2.关键词
当归/茯苓/过敏性鼻炎/网络药理学/作用机制Key words
Angelica sinensis/Poria cocos/allergic rhinitis/network pharmacology/mechanism of action分类
医药卫生引用本文复制引用
程静凯,朱珊,田新磊,胡文杰,史兴婵,乔淑楠..当归-茯苓药对干预过敏性鼻炎的作用机制预测及验证[J].中国药房,2025,36(22):2778-2782,5.基金项目
第七批全国老中医药专家学术经验继承工作项目(No.国中医药人教函[2022]76号) （No.国中医药人教函[2022]76号）
河南省自然科学基金面上科学基金项目(No.232300421188) （No.232300421188）
河南省中医药青苗人才第二批培养项目(No.豫卫中医函[2021]16号) （No.豫卫中医函[2021]16号）
