中国药房2025，Vol.36Issue(22)：2790-2795,6.DOI:10.6039/j.issn.1001-0408.2025.22.07
开心颗粒的水提工艺优化
Optimization of water extraction technology of Kaixin granules
摘要
Abstract
OBJECTIVE To optimize the water extraction technology for Kaixin granules.METHODS UPLC-MS/MS method was established for the simultaneous determination of ginsenoside Rg1,ginsenoside Re,ginsenoside Rb1,tenuifolin,polygalaxanthone Ⅲ and 3,6′-disinapoyl-sucrose.An orthogonal test was designed with extraction times,extraction duration,and the volume of added water as factors.Using the contents of the aforementioned six indicator components and the extract yield as evaluation indexes,analytic hierarchy process-entropy weight method was employed to determine the combined weights of each indicator.Subsequently,process optimization and validation were conducted by integrating grey relational analysis(GRA)and back propagation(BP)neural network.RESULTS The water extraction technology optimized by the orthogonal test and GRA was 10-fold water for the first decoction and 8-fold water for the subsequent two,extracting 3 times,extracting for 1 h each time;the average comprehensive score of the validation experiment was 91.10(RSD=0.31%,n=3).The water extraction technology optimized by BP neural network was extracting 3 times with 10-fold water added each time,extracting for 1.5 h each time;the average comprehensive score of the validation experiment was 95.89(RSD=0.73%,n=3).Considering practical production requirements,the optimal water extraction technology was extraction performed three times,with 10-fold water for the first decoction and 8-fold water for the subsequent two extractions,with an extraction time of 1 h each.CONCLUSIONS The optimized water extraction technology for Kaixin granules is stable and feasible.关键词
开心颗粒/水提工艺/层次分析法/熵权法/灰色关联度分析/正交实验/BP神经网络Key words
Kaixin granules/water extraction technology/analytic hierarchy process/entropy weight method/grey relational analysis/orthogonal test/BP neural network分类
药学引用本文复制引用
吴作敏,于晓涛,白淑贤,宁萌,王韵旨,马慧芬,董敬远,杨忠杰,谢治深,张振强..开心颗粒的水提工艺优化[J].中国药房,2025,36(22):2790-2795,6.基金项目
河南省重点研发专项(No.231111312900) （No.231111312900）
河南省医学科技攻关计划项目(No.LHGJ20250923) （No.LHGJ20250923）
漯河市重大科技创新专项(No.漯财预指[2022]478号) （No.漯财预指[2022]478号）
漯河市科技创新券兑现资金项目(No.漯创体办[2023]1号) （No.漯创体办[2023]1号）
